| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| TGAM_0342 | priA | TGAM_0342 | TGAM_0343 | Membrane transport protein; 10 probable transmembrane helices predicted by modhmm. | DNA primase small subunit (priA); Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synt [...] | 0.916 |
| TGAM_0342 | priB | TGAM_0342 | TGAM_0344 | Membrane transport protein; 10 probable transmembrane helices predicted by modhmm. | DNA primase large subunit (priB); Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. | 0.915 |
| cdc6 | dp1 | TGAM_0128 | TGAM_0127 | Cell division control protein 6-like protein (cdc6); Involved in regulation of DNA replication. | DNA polymerase II small subunit (dp1/polB); Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family. | 0.994 |
| cdc6 | fen | TGAM_0128 | TGAM_1199 | Cell division control protein 6-like protein (cdc6); Involved in regulation of DNA replication. | Flap structure-specific endonuclease (fen); Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision [...] | 0.760 |
| cdc6 | mcm2 | TGAM_0128 | TGAM_2024 | Cell division control protein 6-like protein (cdc6); Involved in regulation of DNA replication. | DNA replication licensing factor, Mcm2/Cdc19 ATPase, containing 2 inteins (Mcm2/Cdc19); Contains 2 Hint (Hedgehog/Intein) domains; Belongs to the MCM family. | 0.993 |
| cdc6 | pcnA | TGAM_0128 | TGAM_1046 | Cell division control protein 6-like protein (cdc6); Involved in regulation of DNA replication. | DNA polymerase sliding clamp (Proliferating cell nuclear antigen-like protein) (PCNA) (pcnA); Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | 0.760 |
| cdc6 | pol | TGAM_0128 | TGAM_1455 | Cell division control protein 6-like protein (cdc6); Involved in regulation of DNA replication. | DNA-directed DNA polymerase, B family (pol). | 0.884 |
| cdc6 | priA | TGAM_0128 | TGAM_0343 | Cell division control protein 6-like protein (cdc6); Involved in regulation of DNA replication. | DNA primase small subunit (priA); Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synt [...] | 0.929 |
| cdc6 | priB | TGAM_0128 | TGAM_0344 | Cell division control protein 6-like protein (cdc6); Involved in regulation of DNA replication. | DNA primase large subunit (priB); Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. | 0.937 |
| cdc6 | rfcL | TGAM_0128 | TGAM_2063 | Cell division control protein 6-like protein (cdc6); Involved in regulation of DNA replication. | Replication factor C, large subunit (rfcL); Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. | 0.656 |
| cdc6 | rnhB | TGAM_0128 | TGAM_1091 | Cell division control protein 6-like protein (cdc6); Involved in regulation of DNA replication. | Ribonuclease HII (rnhB); Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | 0.759 |
| dp1 | cdc6 | TGAM_0127 | TGAM_0128 | DNA polymerase II small subunit (dp1/polB); Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family. | Cell division control protein 6-like protein (cdc6); Involved in regulation of DNA replication. | 0.994 |
| dp1 | fen | TGAM_0127 | TGAM_1199 | DNA polymerase II small subunit (dp1/polB); Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family. | Flap structure-specific endonuclease (fen); Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision [...] | 0.950 |
| dp1 | pcnA | TGAM_0127 | TGAM_1046 | DNA polymerase II small subunit (dp1/polB); Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family. | DNA polymerase sliding clamp (Proliferating cell nuclear antigen-like protein) (PCNA) (pcnA); Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | 0.999 |
| dp1 | pol | TGAM_0127 | TGAM_1455 | DNA polymerase II small subunit (dp1/polB); Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family. | DNA-directed DNA polymerase, B family (pol). | 0.982 |
| dp1 | priA | TGAM_0127 | TGAM_0343 | DNA polymerase II small subunit (dp1/polB); Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family. | DNA primase small subunit (priA); Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synt [...] | 0.912 |
| dp1 | priB | TGAM_0127 | TGAM_0344 | DNA polymerase II small subunit (dp1/polB); Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family. | DNA primase large subunit (priB); Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. | 0.953 |
| dp1 | rfcL | TGAM_0127 | TGAM_2063 | DNA polymerase II small subunit (dp1/polB); Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family. | Replication factor C, large subunit (rfcL); Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. | 0.507 |
| dp1 | rnhB | TGAM_0127 | TGAM_1091 | DNA polymerase II small subunit (dp1/polB); Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family. | Ribonuclease HII (rnhB); Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | 0.787 |
| fen | cdc6 | TGAM_1199 | TGAM_0128 | Flap structure-specific endonuclease (fen); Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision [...] | Cell division control protein 6-like protein (cdc6); Involved in regulation of DNA replication. | 0.760 |
