STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ccatRNA nucleotidyltransferase (CCA adding enzyme) (cca); Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. (454 aa)    
Predicted Functional Partners:
ligT
2'-5' RNA ligase (ligT); Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family.
 
     0.823
TGAM_0421
Phosphoribosyltransferase.
       0.689
TGAM_0905
Conserved hypothetical protein; Belongs to DUF655 family; Contains DNA polymerase beta, N-terminal-like domain.
 
   
 0.678
nac
Nascent polypeptide-associated complex protein (nac); Contacts the emerging nascent chain on the ribosome. Belongs to the NAC-alpha family.
 
     0.677
moeB
Molybdopterin or thiamine synthase protein (moeB/thiF).
  
 
 0.651
endA
tRNA-splicing endonuclease (endA); Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
 
   
 0.636
dnaG
Primase-related protein; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.
 
   
 0.630
TGAM_0133
Conserved hypothetical protein; Belongs to DUF75 family.
 
   
 0.604
rpoE2
DNA-directed RNA polymerase subunit E' (rpoE2); Stimulates transcription elongation; Belongs to the archaeal Spt4 family.
  
     0.573
TGAM_0614
Conserved hypothetical protein; Belongs to DUF112 family; 9 probable transmembrane helices predicted by modhmm.
  
     0.553
Your Current Organism:
Thermococcus gammatolerans
NCBI taxonomy Id: 593117
Other names: T. gammatolerans EJ3, Thermococcus gammatolerans EJ3, Thermococcus gammatolerans str. EJ3, Thermococcus gammatolerans strain EJ3
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.