Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
TGAM_0434Phosphoesterase, putative; Contains PHP domain. (421 aa)    
Predicted Functional Partners:
TGAM_0433
Voltage-gated ClC-type chloride channel; 12 probable transmembrane helices predicted by modhmm.
       0.910
TGAM_0432
Conserved hypothetical protein.
       0.834
thiL
Thiamine monophosphate kinase (thiL); Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family.
       0.792
TGAM_0441
Polysaccharide deacetylase, putative.
       0.728
TGAM_0442
Radical SAM family protein, lectins/glucanases related.
       0.697
TGAM_0443
Conserved hypothetical protein.
       0.697
TGAM_0435
Transcription regulator, SpoVT/AbrB family.
       0.647
TGAM_0439
Conserved hypothetical protein; Belongs to UPF0104 family; 5 probable transmembrane helices predicted by modhmm.
       0.588
eIF2A
Translation initiation factor 2 alpha subunit (eIF2A); eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-alpha family.
       0.576
nop10
Nucleolar RNA-binding protein, Nop10p family; Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.
       0.576
Your Current Organism:
Thermococcus gammatolerans
NCBI taxonomy Id: 593117
Other names: T. gammatolerans EJ3, Thermococcus gammatolerans EJ3, Thermococcus gammatolerans str. EJ3, Thermococcus gammatolerans strain EJ3
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