Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
TGAM_0477Archaeal histone B (Archaeal histone A2). (67 aa)    
Predicted Functional Partners:
tfe
Transcription factor TFIIE subunit alpha-like protein (tfe); Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and desta [...]
  
   
 0.617
TGAM_1403
Predicted membrane protein; Belongs to DUF63 family; 5 probable transmembrane helices predicted by modhmm.
  
     0.553
thrS
Threonyl-tRNA synthetase (thrS); Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr); Belongs to the class-II aminoacyl-tRNA synthetase family.
  
    0.536
albA
DNA-binding protein Alba (albA); Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes; Belongs to the histone-like Alba family.
  
   
 0.517
TGAM_0605
Conserved hypothetical protein; Belongs to UPF0146 family.
  
     0.507
atpE
Archaeal/vacuolar-type H+-ATPase, subunit E (atpE); Produces ATP from ADP in the presence of a proton gradient across the membrane.
  
     0.489
rbcL
Ribulose 1,5-bisphosphate carboxylase large subunit (RuBisCO) (rbcL); Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase. Belongs to the RuBisCO large chain family. Type III subfamily.
       0.483
TGAM_1760
Replication factor A complex, RPA41 subunit; Subunit of the RPA hetero-oligomeric complex.
 
  
 0.482
TGAM_1935
ATPase, AAA superfamily, containing PIN and KH nucleic acid-binding domains.
 
     0.481
TGAM_0478
Conserved hypothetical protein; 1 probable transmembrane helix predicted by modhmm.
       0.471
Your Current Organism:
Thermococcus gammatolerans
NCBI taxonomy Id: 593117
Other names: T. gammatolerans EJ3, Thermococcus gammatolerans EJ3, Thermococcus gammatolerans str. EJ3, Thermococcus gammatolerans strain EJ3
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