Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
TGAM_0504Methylase, putative, hemK and PrmA related; Location of this gene downstream of S24E and S27AE ribosomal proteins suggests it might be ribosomal protein L11 methyltransferase (PrmA). (195 aa)    
Predicted Functional Partners:
rpoE1
DNA-directed RNA polymerase subunit E' (rpoE1).
 
     0.901
rps27AE
SSU ribosomal protein S27AE (rps27AE); Belongs to the eukaryotic ribosomal protein eS31 family.
 
     0.901
rps24E
SSU ribosomal protein S24E (rps24E); Belongs to the eukaryotic ribosomal protein eS24 family.
   
   0.890
rpoE2
DNA-directed RNA polymerase subunit E' (rpoE2); Stimulates transcription elongation; Belongs to the archaeal Spt4 family.
       0.882
TGAM_0501
Conserved hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).
       0.882
eRF1
Peptide chain release factor eRF/aRF, subunit 1 (eRF1/prf1); Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
   
 0.875
ppa
Inorganic pyrophosphatase (ppa); Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
       0.822
atpK
Archaeal/vacuolar-type H+-ATPase, subunit K (atpK); 4 probable transmembrane helices predicted by modhmm.
  
   0.601
taw1
Radical SAM protein; Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
       0.599
TGAM_0787
RNA methylase, putative; Belongs to UPF0020 family.
    
 
 0.571
Your Current Organism:
Thermococcus gammatolerans
NCBI taxonomy Id: 593117
Other names: T. gammatolerans EJ3, Thermococcus gammatolerans EJ3, Thermococcus gammatolerans str. EJ3, Thermococcus gammatolerans strain EJ3
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