Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Gene Fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
TGAM_0618DNA helicase, putative. (660 aa)    
Predicted Functional Partners:
TGAM_0619
Conserved hypothetical protein.
       0.804
taw3-2
Conserved hypothetical protein; S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72; Belongs to the TYW3 family.
 
     0.706
TGAM_1937
ATP binding protein, XPA-binding protein 1-like protein.
   
 0.659
eIF2A
Translation initiation factor 2 alpha subunit (eIF2A); eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-alpha family.
  
 
 0.595
TGAM_1687
mRNA 3-end processing factor, putative; Contains 1 Metallo-hydrolase/oxidoreductase fold (SSF56281).
   
 0.580
rpl3P
LSU ribosomal protein L3P (rpl3P); One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family.
 
  0.576
TGAM_0970
WD40-domain containing protein; 1 probable transmembrane helix predicted by modhmm.
  
 0.569
TGAM_1486
Conserved hypothetical protein; Contains 3 WD-40 repeat units; 2 probable transmembrane helices predicted by modhmm.
   
 0.569
TGAM_1623
Type III restriction endonuclease, res subunit; Belongs to DEAD-like/ SNF2 superfamily. mod subunit is tg1624.
   
 0.566
tyrP
Transmembrane amino acid transporter, tyrosine-specific (tyrP); 10 probable transmembrane helices predicted by modhmm.
  
 
 
 0.560
Your Current Organism:
Thermococcus gammatolerans
NCBI taxonomy Id: 593117
Other names: T. gammatolerans EJ3, Thermococcus gammatolerans EJ3, Thermococcus gammatolerans str. EJ3, Thermococcus gammatolerans strain EJ3
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