Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
Experiments
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[Homology]
Score
nadAQuinolinate synthetase A (nadA); Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (302 aa)    
Predicted Functional Partners:
nadB
L-aspartate oxidase (quinolinate synthetase B) (nadB); Catalyzes the oxidation of L-aspartate to iminoaspartate.
 
 0.999
nadC-2
Nicotinate-nucleotide pyrophosphorylase (Quinolinate phosphoribosyltransferase) (nadC); Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.
 
 
 0.999
TGAM_0622
Conserved hypothetical protein; 6 probable transmembrane helices predicted by modhmm.
       0.499
ftsZ-2
Cell division GTPase, ftsZ-like protein (ftsZ); Involved in cell shape control; Belongs to the CetZ family.
     
 0.491
tmk
Thymidylate kinase (dTMP kinase) (tmk).
     
 0.480
nadE
NH(3)-dependent NAD synthetase (nadE); Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
  
  
 0.459
valS
Valyl-tRNA synthetase (valS); Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
      0.451
ogt
Methylated-DNA--protein-cysteine methyltransferase (ogt); Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
  
  
 0.449
TGAM_1855
Amino acid transporter; 12 probable transmembrane helices predicted by modhmm.
     
 0.437
TGAM_0959
Carbon-nitrogen hydrolase.
     
 0.409
Your Current Organism:
Thermococcus gammatolerans
NCBI taxonomy Id: 593117
Other names: T. gammatolerans EJ3, Thermococcus gammatolerans EJ3, Thermococcus gammatolerans str. EJ3, Thermococcus gammatolerans strain EJ3
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