Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
TGAM_0716Conserved hypothetical protein; 2 probable transmembrane helices predicted by modhmm. (526 aa)    
Predicted Functional Partners:
hjc
Archaeal holliday junction resolvase (Hjc); A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products; Belongs to the Holliday junction resolvase Hjc family.
       0.914
TGAM_0718
Carbonic anhydrase/acetyltransferase, containing bacterial transferase hexapeptide repeat.
       0.833
uppS
Undecaprenyl pyrophosphate synthetase (Di-trans-poly-cis-decaprenylcistransferase) (uppS); Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
       0.833
TGAM_0861
M42 family glutamyl aminopeptidase, de-blocking aminopeptidase.
       0.649
cyaB-1
Adenylate cyclase type 2, thermophiic (CyaB).
       0.635
amzA
Zinc-dependent protease, archaeal type, predicted; Probable zinc metalloprotease whose natural substrate is unknown.
       0.603
tip
TBP-interacting protein (tip).
       0.580
TGAM_0858
Conserved hypothetical protein.
       0.513
TGAM_1009
Conserved hypothetical protein.
       0.507
Your Current Organism:
Thermococcus gammatolerans
NCBI taxonomy Id: 593117
Other names: T. gammatolerans EJ3, Thermococcus gammatolerans EJ3, Thermococcus gammatolerans str. EJ3, Thermococcus gammatolerans strain EJ3
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