Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
pgk22-phosphoglycerate kinase, containing ATP cone domain. (290 aa)    
Predicted Functional Partners:
cdpgs
Cyclic 2,3-diphosphoglycerate synthase (cdpgs); Catalyzes the formation of cyclic 2,3-diphosphoglycerate (cDPG) by formation of an intramolecular phosphoanhydride bond at the expense of ATP.
 
   
 0.974
TGAM_0726
Conserved hypothetical protein; Contains 1 Histone-fold domain.
       0.824
TGAM_0727
Metal-dependent hydrolase, beta-lactamase superfamily.
       0.660
apgM
2,3-bisphosphoglycerate-independent phosphoglycerate mutase (apgM); Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate.
  
   
 0.581
TGAM_0723
Metallophosphoesterase, Calcineurin-like phosphoesterase family.
 
     0.551
pyk
Pyruvate kinase (pyk); Belongs to the pyruvate kinase family.
      
 0.478
pfkC
ADP-specific phosphofructokinase (pfkC); Catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate using ADP as the phosphate donor.
  
   
 0.466
TGAM_0184
Conserved hypothetical protein; Contains 1 ProFAR isomerase associated domain.
  
     0.406
ppsA
Phosphoenolpyruvate synthase (pyruvate,water dikinase) (PEP synthase) (ppsA); Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family.
      
 0.404
TGAM_1073
Conserved hypothetical protein; 3 probable transmembrane helices predicted by modhmm.
  
     0.401
Your Current Organism:
Thermococcus gammatolerans
NCBI taxonomy Id: 593117
Other names: T. gammatolerans EJ3, Thermococcus gammatolerans EJ3, Thermococcus gammatolerans str. EJ3, Thermococcus gammatolerans strain EJ3
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.