Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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cdpgsCyclic 2,3-diphosphoglycerate synthase (cdpgs); Catalyzes the formation of cyclic 2,3-diphosphoglycerate (cDPG) by formation of an intramolecular phosphoanhydride bond at the expense of ATP. (438 aa)    
Predicted Functional Partners:
pgk2
2-phosphoglycerate kinase, containing ATP cone domain.
 
   
 0.974
TGAM_0726
Conserved hypothetical protein; Contains 1 Histone-fold domain.
     
 0.860
TGAM_0723
Metallophosphoesterase, Calcineurin-like phosphoesterase family.
 
     0.667
TGAM_0727
Metal-dependent hydrolase, beta-lactamase superfamily.
       0.660
nusA-1
Transcription elongation factor, putative NusA-like protein (nusA); Contains 1 KH domain.
  
     0.532
TGAM_1073
Conserved hypothetical protein; 3 probable transmembrane helices predicted by modhmm.
  
     0.491
TGAM_1416
tRNA-binding protein, putative.
  
     0.481
priA
DNA primase small subunit (priA); Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synt [...]
  
     0.470
TGAM_1498
Brix-domain ribosomal biogenesis protein; Probably involved in the biogenesis of the ribosome.
  
     0.432
TGAM_1372
Conserved hypothetical protein; Belongs to DUF192 family; Belongs to the UPF0127 family.
  
     0.411
Your Current Organism:
Thermococcus gammatolerans
NCBI taxonomy Id: 593117
Other names: T. gammatolerans EJ3, Thermococcus gammatolerans EJ3, Thermococcus gammatolerans str. EJ3, Thermococcus gammatolerans strain EJ3
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