Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
TGAM_0743Conserved hypothetical protein. (332 aa)    
Predicted Functional Partners:
TGAM_0745
Conserved hypothetical protein; Contains band 7 domain of flotillin (reggie) like proteins; 2 probable transmembrane helices predicted by modhmm.
 
     0.967
TGAM_0744
Conserved hypothetical protein.
 
     0.965
TGAM_0746
Conserved hypothetical protein; 2 probable transmembrane helices predicted by modhmm.
 
     0.955
purE
Phosphoribosylaminoimidazole carboxylase, catalytic subunit (AIR carboxylase) (purE); Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).
 
     0.609
TGAM_1937
ATP binding protein, XPA-binding protein 1-like protein.
  
 0.588
TGAM_1405
Peptidase, putative, Rhomboid-like protein protein; 6 probable transmembrane helices predicted by modhmm.
 
 0.529
pan
ATP-dependent 26S proteasome regulatory subunit P45 family; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP bindin [...]
   
 
 0.524
rps8E
SSU ribosomal protein S8E (rps8E).
  
    0.511
gar1
Gar1-like small nucleolar rnp, putative (gar1).
  
    0.500
purD
Phosphoribosylamine--glycine ligase (purD).
 
   0.489
Your Current Organism:
Thermococcus gammatolerans
NCBI taxonomy Id: 593117
Other names: T. gammatolerans EJ3, Thermococcus gammatolerans EJ3, Thermococcus gammatolerans str. EJ3, Thermococcus gammatolerans strain EJ3
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.