Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
TGAM_0748Conserved hypothetical protein. (249 aa)    
Predicted Functional Partners:
TGAM_0749
Conserved hypothetical protein.
       0.914
purD
Phosphoribosylamine--glycine ligase (purD).
       0.843
purE
Phosphoribosylaminoimidazole carboxylase, catalytic subunit (AIR carboxylase) (purE); Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).
       0.842
purP
IMP biosynthesis enzyme (5-formaminoimidazole-4-carboxamide-1-(beta)-D- ribofuranosyl 5'-monophosphate synthetase) (purP).
       0.838
purS
Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component (purS); Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and Pur [...]
       0.537
purQ
Phosphoribosylformylglycinamidine synthase I, purQ component (purQ); Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and [...]
       0.537
TGAM_0752
Hypothetical protein; 1 probable transmembrane helix predicted by modhmm.
       0.433
TGAM_0744
Conserved hypothetical protein.
       0.401
TGAM_0745
Conserved hypothetical protein; Contains band 7 domain of flotillin (reggie) like proteins; 2 probable transmembrane helices predicted by modhmm.
       0.401
TGAM_0746
Conserved hypothetical protein; 2 probable transmembrane helices predicted by modhmm.
       0.401
Your Current Organism:
Thermococcus gammatolerans
NCBI taxonomy Id: 593117
Other names: T. gammatolerans EJ3, Thermococcus gammatolerans EJ3, Thermococcus gammatolerans str. EJ3, Thermococcus gammatolerans strain EJ3
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