Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
TGAM_0799Serine/threonine protein kinase, putative S-layer protein; Contains 1 beta-propeller YVTN-type domain in Nterm, 1 PEGA domain in central part and 1 protein kinase domain in Cterm; 2 probable transmembrane helices predicted by modhmm. (1292 aa)    
Predicted Functional Partners:
pp2C
Serine/threonine protein phosphatase 2C (PP2C); 2 probable transmembrane helices predicted by modhmm.
 
 0.849
TGAM_0429
Acetylpolyamine amidohydrolase, histone deacetylase superfamily.
  
 
 0.583
TGAM_1937
ATP binding protein, XPA-binding protein 1-like protein.
   
 0.583
TGAM_1460
recJ-like phosphoesterase, containing RNA binding S1 and OB-fold nucleic acid binding domain.
    
 0.510
TGAM_0970
WD40-domain containing protein; 1 probable transmembrane helix predicted by modhmm.
   
 
 0.497
TGAM_1486
Conserved hypothetical protein; Contains 3 WD-40 repeat units; 2 probable transmembrane helices predicted by modhmm.
   
 
 0.497
pcp
Pyrrolidone-carboxylate peptidase (pcp); Removes 5-oxoproline from various penultimate amino acid residues except L-proline; Belongs to the peptidase C15 family.
  
   0.486
ndk
Nucleoside diphosphate kinase (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
    
 
 0.480
TGAM_0798
Conserved hypothetical protein; 2 probable transmembrane helices predicted by modhmm.
       0.442
TGAM_1218
Short chain dehydrogenase of unknown substrate; Match to IPR002347 Glucose/ribitol dehydrogenase indicates that the protein is not an alcohol dehydrogenase, but another type of dehydrogenase or reductase.
  
 0.407
Your Current Organism:
Thermococcus gammatolerans
NCBI taxonomy Id: 593117
Other names: T. gammatolerans EJ3, Thermococcus gammatolerans EJ3, Thermococcus gammatolerans str. EJ3, Thermococcus gammatolerans strain EJ3
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