eIF2A protein (Thermococcus gammatolerans) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

eIF2A

Translation initiation factor 2 alpha subunit (eIF2A); eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-alpha family. (273 aa)

Predicted Functional Partners:

eIF2G

0.997

eIF1A

0.996

eif2b

0.996

rps3AE

0.992

rps3P

0.991

nop10

0.989

rps10P

0.985

rps6E

0.984

rps5P

0.980

rps19P

0.978

Your Current Organism:

Thermococcus gammatolerans

NCBI taxonomy Id: 593117
Other names: T. gammatolerans EJ3, Thermococcus gammatolerans EJ3, Thermococcus gammatolerans str. EJ3, Thermococcus gammatolerans strain EJ3

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
eIF1A	eIF2A	TGAM_1422	TGAM_0809	eIF1A translation initiation factor eIF-1A (eIF1A); Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.	Translation initiation factor 2 alpha subunit (eIF2A); eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-alpha family.	0.996
eIF1A	eIF2G	TGAM_1422	TGAM_1286	eIF1A translation initiation factor eIF-1A (eIF1A); Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.	Translation initiation factor eIF-2, subunit gamma (eIF2G) (eIF2G); eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.	0.995
eIF1A	eif2b	TGAM_1422	TGAM_2025	eIF1A translation initiation factor eIF-1A (eIF1A); Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.	Translation initiation factor 2 beta subunit (eif2b); eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-beta/eIF-5 family.	0.996
eIF1A	rps10P	TGAM_1422	TGAM_1055	eIF1A translation initiation factor eIF-1A (eIF1A); Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.	SSU ribosomal protein S10P (rps10P); Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family.	0.984
eIF1A	rps19P	TGAM_1422	TGAM_1999	eIF1A translation initiation factor eIF-1A (eIF1A); Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.	SSU ribosomal protein S19P (rps19P); Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.	0.992
eIF1A	rps3AE	TGAM_1422	TGAM_0862	eIF1A translation initiation factor eIF-1A (eIF1A); Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.	SSU ribosomal protein S3AE (rps3AE); Belongs to the eukaryotic ribosomal protein eS1 family.	0.936
eIF1A	rps3P	TGAM_1422	TGAM_1997	eIF1A translation initiation factor eIF-1A (eIF1A); Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.	SSU ribosomal protein S3P (rps3P); Binds the lower part of the 30S subunit head. Belongs to the universal ribosomal protein uS3 family.	0.983
eIF1A	rps5P	TGAM_1422	TGAM_1982	eIF1A translation initiation factor eIF-1A (eIF1A); Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.	SSU ribosomal protein S5P (rps5P); With S4 and S12 plays an important role in translational accuracy.	0.987
eIF1A	rps6E	TGAM_1422	TGAM_1634	eIF1A translation initiation factor eIF-1A (eIF1A); Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.	SSU ribosomal protein S6E (rps6E); Belongs to the eukaryotic ribosomal protein eS6 family.	0.904
eIF2A	eIF1A	TGAM_0809	TGAM_1422	Translation initiation factor 2 alpha subunit (eIF2A); eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-alpha family.	eIF1A translation initiation factor eIF-1A (eIF1A); Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.	0.996
eIF2A	eIF2G	TGAM_0809	TGAM_1286	Translation initiation factor 2 alpha subunit (eIF2A); eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-alpha family.	Translation initiation factor eIF-2, subunit gamma (eIF2G) (eIF2G); eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.	0.997
eIF2A	eif2b	TGAM_0809	TGAM_2025	Translation initiation factor 2 alpha subunit (eIF2A); eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-alpha family.	Translation initiation factor 2 beta subunit (eif2b); eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-beta/eIF-5 family.	0.996
eIF2A	nop10	TGAM_0809	TGAM_0810	Translation initiation factor 2 alpha subunit (eIF2A); eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-alpha family.	Nucleolar RNA-binding protein, Nop10p family; Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.	0.989
eIF2A	rps10P	TGAM_0809	TGAM_1055	Translation initiation factor 2 alpha subunit (eIF2A); eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-alpha family.	SSU ribosomal protein S10P (rps10P); Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family.	0.985
eIF2A	rps19P	TGAM_0809	TGAM_1999	Translation initiation factor 2 alpha subunit (eIF2A); eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-alpha family.	SSU ribosomal protein S19P (rps19P); Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.	0.978
eIF2A	rps3AE	TGAM_0809	TGAM_0862	Translation initiation factor 2 alpha subunit (eIF2A); eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-alpha family.	SSU ribosomal protein S3AE (rps3AE); Belongs to the eukaryotic ribosomal protein eS1 family.	0.992
eIF2A	rps3P	TGAM_0809	TGAM_1997	Translation initiation factor 2 alpha subunit (eIF2A); eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-alpha family.	SSU ribosomal protein S3P (rps3P); Binds the lower part of the 30S subunit head. Belongs to the universal ribosomal protein uS3 family.	0.991
eIF2A	rps5P	TGAM_0809	TGAM_1982	Translation initiation factor 2 alpha subunit (eIF2A); eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-alpha family.	SSU ribosomal protein S5P (rps5P); With S4 and S12 plays an important role in translational accuracy.	0.980
eIF2A	rps6E	TGAM_0809	TGAM_1634	Translation initiation factor 2 alpha subunit (eIF2A); eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-alpha family.	SSU ribosomal protein S6E (rps6E); Belongs to the eukaryotic ribosomal protein eS6 family.	0.984
eIF2G	eIF1A	TGAM_1286	TGAM_1422	Translation initiation factor eIF-2, subunit gamma (eIF2G) (eIF2G); eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.	eIF1A translation initiation factor eIF-1A (eIF1A); Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.	0.995

page 1 of 5

Server load: low (12%) [HD]

Permalink

Network

Neighborhood

Experiments

Co-occurrence

Databases

Co-expression

Textmining

Fusion

© STRING Consortium 2026

Credits

Access

Info

About