Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
TGAM_0905Conserved hypothetical protein; Belongs to DUF655 family; Contains DNA polymerase beta, N-terminal-like domain. (206 aa)    
Predicted Functional Partners:
rpl21E
LSU ribosomal protein L21E (rpl21E); Belongs to the eukaryotic ribosomal protein eL21 family.
 
  
 0.948
ksgA
Ribosomal RNA adenine methylase transferase (Dimethyladenosine transferase) (ksgA); Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
     
 0.927
rpoF
DNA-directed RNA polymerase subunit F (rpoF).
 
   
 0.883
pus10
RNA-binding protein, pseudouridine synthase family; Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.
 
     0.798
dnaG
Primase-related protein; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.
  
     0.739
gcvH
Glycine cleavage system protein H (gcvH); The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
       0.728
TGAM_0902
Conserved hypothetical protein.
       0.690
TGAM_0910
Putative transcription regulator.
       0.677
cca
tRNA nucleotidyltransferase (CCA adding enzyme) (cca); Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
  
   
 0.675
nac
Nascent polypeptide-associated complex protein (nac); Contacts the emerging nascent chain on the ribosome. Belongs to the NAC-alpha family.
  
     0.663
Your Current Organism:
Thermococcus gammatolerans
NCBI taxonomy Id: 593117
Other names: T. gammatolerans EJ3, Thermococcus gammatolerans EJ3, Thermococcus gammatolerans str. EJ3, Thermococcus gammatolerans strain EJ3
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