Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
TGAM_0925Met-10 like-protein, putative SAM-dependent methyltransferase. (331 aa)    
Predicted Functional Partners:
TGAM_0276
Histone acetyltransferase-like protein; Contains Elp3 (Elongator protein 3), belongs to GNAT methyltransferases family.
 
  
 0.647
dph5
Diphthine synthase (Diphtamide biosynthesis methyltransferase) (dph5); S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
 
  
 0.644
TGAM_1424
RNA-binding protein, containing KH domain.
 
    0.574
taw1
Radical SAM protein; Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
 
  
 0.565
eif2b
Translation initiation factor 2 beta subunit (eif2b); eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-beta/eIF-5 family.
  
    0.543
ksgA
Ribosomal RNA adenine methylase transferase (Dimethyladenosine transferase) (ksgA); Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
  
  
 0.534
eRF1
Peptide chain release factor eRF/aRF, subunit 1 (eRF1/prf1); Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
 
    0.515
psmA
Peptidase T1A, 20S proteasome alpha-subunit (psmA); Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
 
     0.507
TGAM_0020
PP-loop ATPase, YdaO-type.
  
  
 0.506
aeF1-B
Translation elongation factor aEF-1, subunit beta (aeF1-B); Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.
     
 0.489
Your Current Organism:
Thermococcus gammatolerans
NCBI taxonomy Id: 593117
Other names: T. gammatolerans EJ3, Thermococcus gammatolerans EJ3, Thermococcus gammatolerans str. EJ3, Thermococcus gammatolerans strain EJ3
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.