Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
TGAM_0966ATPase of the AAA family. (383 aa)    
Predicted Functional Partners:
TGAM_0968
Serine/threonine protein kinase; 2 probable transmembrane helices predicted by modhmm.
   
 0.866
TGAM_0967
Hypothetical protein.
       0.826
TGAM_0970
WD40-domain containing protein; 1 probable transmembrane helix predicted by modhmm.
  
 
 0.806
TGAM_0969
Conserved hypothetical protein; Contains quinoprotein alcohol dehydrogenase-like signature; 1 probable transmembrane helix predicted by modhmm.
       0.773
pp2C
Serine/threonine protein phosphatase 2C (PP2C); 2 probable transmembrane helices predicted by modhmm.
  
 
 0.717
TGAM_0429
Acetylpolyamine amidohydrolase, histone deacetylase superfamily.
   
 0.658
TGAM_0974
Serine/threonine protein kinase.
   
 0.587
TGAM_1460
recJ-like phosphoesterase, containing RNA binding S1 and OB-fold nucleic acid binding domain.
   
 
 0.568
rpl40E
LSU ribosomal protein L40E (rpl40E); Belongs to the eukaryotic ribosomal protein eL40 family.
   
 0.566
pan
ATP-dependent 26S proteasome regulatory subunit P45 family; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP bindin [...]
 
0.556
Your Current Organism:
Thermococcus gammatolerans
NCBI taxonomy Id: 593117
Other names: T. gammatolerans EJ3, Thermococcus gammatolerans EJ3, Thermococcus gammatolerans str. EJ3, Thermococcus gammatolerans strain EJ3
Server load: low (8%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.