Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
TGAM_1007Small conductance mechanosensitive channel (MscS); 4 probable transmembrane helices predicted by modhmm. (376 aa)    
Predicted Functional Partners:
TGAM_1006
Conserved hypothetical protein; Belongs to DUF432 family; 1 probable transmembrane helix predicted by modhmm.
       0.914
thrS
Threonyl-tRNA synthetase (thrS); Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr); Belongs to the class-II aminoacyl-tRNA synthetase family.
 
    0.795
TGAM_1279
Conserved hypothetical protein; Contains a duplicated domain; 1 probable transmembrane helix predicted by modhmm.
       0.649
TGAM_1281
Conserved hypothetical protein; Belongs to DUF434 family.
       0.642
TGAM_1282
Phosphohydrolase, putative; Contains metal dependent phosphohydrolases HD domain (SM00471).
       0.629
rpoL
DNA-directed RNA polymerase subunit L (rpoL); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoL/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
       0.611
TGAM_1004
Conserved hypothetical protein.
       0.611
csl4
RNA-binding protein, containing S1 RNA binding domain; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.
       0.611
TGAM_1001
Conserved hypothetical protein.
       0.571
TGAM_1002
Conserved hypothetical protein; 8 probable transmembrane helices predicted by modhmm.
       0.558
Your Current Organism:
Thermococcus gammatolerans
NCBI taxonomy Id: 593117
Other names: T. gammatolerans EJ3, Thermococcus gammatolerans EJ3, Thermococcus gammatolerans str. EJ3, Thermococcus gammatolerans strain EJ3
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