Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
thsA-2Thermosome alpha subunit (Thermosome subunit 1) (Chaperonin alpha subunit) (thsA); Belongs to the TCP-1 chaperonin family. (547 aa)    
Predicted Functional Partners:
htpX
Heat shock protein/ Zn-dependent protease with chaperone function, M48 family (htpX); 4 probable transmembrane helices predicted by modhmm; Belongs to the peptidase M48B family.
  
 0.891
pfdA-1
Prefoldin alpha subunit (pfdA); Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.
   
 
 0.866
TGAM_1011
Serine/threonine protein kinase, RIO1 family.
 
  
 0.858
TGAM_1460
recJ-like phosphoesterase, containing RNA binding S1 and OB-fold nucleic acid binding domain.
  
 0.806
TGAM_0468
ATP-dependent protease, archaeal Lon-like protein; 2 probable transmembrane helices predicted by modhmm; Belongs to the peptidase S16 family.
 
 0.798
tbp-2
TATA box-binding protein, transcription initiation factor TFIID (tbp); General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
 
 
 0.790
tbp-1
TATA box-binding protein, transcription initiation factor TFIID (tbp); General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
 
 
 0.773
eIF-5A
Translation initiation factor eIF-5A (hypusine containing) (eIF-5A); Functions by promoting the formation of the first peptide bond; Belongs to the eIF-5A family.
 
 
 0.755
fusA
Translation elongation factor EF-2 (fusA); Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. E [...]
 
 
 0.731
eIF1A
eIF1A translation initiation factor eIF-1A (eIF1A); Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.
 
 
 0.715
Your Current Organism:
Thermococcus gammatolerans
NCBI taxonomy Id: 593117
Other names: T. gammatolerans EJ3, Thermococcus gammatolerans EJ3, Thermococcus gammatolerans str. EJ3, Thermococcus gammatolerans strain EJ3
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.