STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
thiCThiamine biosynthesis protein (thiC); Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (426 aa)    
Predicted Functional Partners:
thiD
Phosphomethylpyrimidine kinase (thiD).
 
 
 0.998
thiS
Sulphur transfer protein, ThiS family (ThiS).
  
  
 0.930
thi4
Thiazole biosynthetic enzyme; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
  
  
 0.862
purO
IMP cyclohydrolase (Inosinicase) (IMP synthetase) (purO); Catalyzes the cyclization of 5-formylamidoimidazole-4- carboxamide ribonucleotide to IMP.
     
 0.848
purC-2
Phosphoribosylaminoimidazole-succinocarboxamide (SAICAR) synthase (purC); Belongs to the SAICAR synthetase family.
     
 0.831
purM
Phosphoribosylformylglycinamidine cyclo-ligase (purM).
    
 0.825
TGAM_1266
Putative carboligase of the ATP-grasp superfamily, C terminal part; N term part is in tg1267. Possibly a true frameshift.
     
 0.812
TGAM_1267
Putative carboligase of the ATP-grasp superfamily; C term part is in tg1266. Possibly a true frameshift.
     
 0.812
moeB
Molybdopterin or thiamine synthase protein (moeB/thiF).
 
  
 0.779
TGAM_2087
Conserved hypothetical protein; Contains a lambda repressor-like DNA-binding domain and a C-terminal Phosphomethylpyrimidine Kinase (PTHR20858) domain.
    
 0.594
Your Current Organism:
Thermococcus gammatolerans
NCBI taxonomy Id: 593117
Other names: T. gammatolerans EJ3, Thermococcus gammatolerans EJ3, Thermococcus gammatolerans str. EJ3, Thermococcus gammatolerans strain EJ3
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