Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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thiDPhosphomethylpyrimidine kinase (thiD). (428 aa)    
Predicted Functional Partners:
thiC
Thiamine biosynthesis protein (thiC); Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.
 
 
 0.999
thi4
Thiazole biosynthetic enzyme; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
 
  
 0.984
thiL
Thiamine monophosphate kinase (thiL); Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family.
 
  
 0.950
TGAM_1555
ATP-binding protein, putative AAA ATPase; Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency; Belongs to the THEP1 NTPase family.
     
 0.903
thiS
Sulphur transfer protein, ThiS family (ThiS).
  
  
 0.874
TGAM_1272
ABC transporter, ATP-binding protein, putative; Contains 1 GCN5-related N-acetyltransferase domain.
       0.870
purC-2
Phosphoribosylaminoimidazole-succinocarboxamide (SAICAR) synthase (purC); Belongs to the SAICAR synthetase family.
     
 0.840
purO
IMP cyclohydrolase (Inosinicase) (IMP synthetase) (purO); Catalyzes the cyclization of 5-formylamidoimidazole-4- carboxamide ribonucleotide to IMP.
       0.834
moeB
Molybdopterin or thiamine synthase protein (moeB/thiF).
 
  
 0.753
TGAM_1266
Putative carboligase of the ATP-grasp superfamily, C terminal part; N term part is in tg1267. Possibly a true frameshift.
       0.661
Your Current Organism:
Thermococcus gammatolerans
NCBI taxonomy Id: 593117
Other names: T. gammatolerans EJ3, Thermococcus gammatolerans EJ3, Thermococcus gammatolerans str. EJ3, Thermococcus gammatolerans strain EJ3
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