Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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panB3-methyl-2-oxobutanoate hydroxymethyltransferase (panB); Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (284 aa)    
Predicted Functional Partners:
panE
2-dehydropantoate reductase (panE); Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
   
 0.997
TGAM_1499
Dolichol-phosphate mannosyltransferase.
  
    0.914
TGAM_1502
SAM-dependent tRNA/rRNA cytosine-C5 methylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
  
  
 0.775
TGAM_1501
Conserved hypothetical protein; Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently (By similarity).
       0.756
TGAM_1503
Conserved hypothetical protein.
       0.755
nadC-2
Nicotinate-nucleotide pyrophosphorylase (Quinolinate phosphoribosyltransferase) (nadC); Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.
      0.731
coaBC
Coenzyme A biosynthesis bifunctional protein coaBC (coaBC); Includes Phosphopantothenoylcysteine decarboxylase and Phosphopantothenate--cysteine ligase.
 
   
 0.610
TGAM_1498
Brix-domain ribosomal biogenesis protein; Probably involved in the biogenesis of the ribosome.
       0.509
TGAM_1497
Conserved hypothetical protein.
       0.490
TGAM_0403
Conserved hypothetical protein; Contains DUF137 domain.
 
   
 0.447
Your Current Organism:
Thermococcus gammatolerans
NCBI taxonomy Id: 593117
Other names: T. gammatolerans EJ3, Thermococcus gammatolerans EJ3, Thermococcus gammatolerans str. EJ3, Thermococcus gammatolerans strain EJ3
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