Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
TGAM_1502SAM-dependent tRNA/rRNA cytosine-C5 methylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (312 aa)    
Predicted Functional Partners:
TGAM_1501
Conserved hypothetical protein; Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently (By similarity).
     
 0.943
TGAM_1503
Conserved hypothetical protein.
       0.914
panB
3-methyl-2-oxobutanoate hydroxymethyltransferase (panB); Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family.
  
  
 0.775
TGAM_1499
Dolichol-phosphate mannosyltransferase.
       0.755
TGAM_0464
pre-mRNA splicing, snoRNA binding protein, NOP5/NOP56 related.
   
 
 0.681
TGAM_0279
Ribosome subunit biogenesis protein, putative; Belongs to UPF0113 family.
  
 
 0.669
TGAM_1498
Brix-domain ribosomal biogenesis protein; Probably involved in the biogenesis of the ribosome.
  
 
 0.656
TGAM_0201
GTP-binding protein, HSR1-related GTPase; Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.
  
 
 0.628
rpl10E-1
LSU ribosomal protein L10E (rpl10E); Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family.
 
 
 0.612
TGAM_0645
GTPase, NOG1/MMR-HSR1 family; Belongs to G-protein superfamily.
   
 
 0.598
Your Current Organism:
Thermococcus gammatolerans
NCBI taxonomy Id: 593117
Other names: T. gammatolerans EJ3, Thermococcus gammatolerans EJ3, Thermococcus gammatolerans str. EJ3, Thermococcus gammatolerans strain EJ3
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