Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
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hisGATP phosphoribosyltransferase (hisG); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (205 aa)    
Predicted Functional Partners:
hisI
Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase (HisI); In the N-terminal section; belongs to the PRA-CH family.
 
 
 0.999
hisB
Imidazoleglycerol-phosphate dehydratase (hisB).
 
  
 0.998
hisZ
ATP phosphoribosyltransferase regulatory subunit, putative (HisZ); Based on BLAST alignments, this is second copy of HisS, shorter at C-terminus. The tRNA synthetase class II motives are not detected in this copy.
 
 0.997
hisD
Histidinol dehydrogenase (hisD); Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
 
  
 0.997
hisH
Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit (hisH); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
 
  
 0.996
hisF
Imidazole glycerol phosphate synthase, cyclase subunit (hisF); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
 
  
 0.996
hisA
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA).
 
  
 0.995
hisC-2
Histidinol-phosphate aminotransferase (hisC).
 
  
 0.987
proC
Pyrroline-5-carboxylate reductase (proC); Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
     
 0.938
TGAM_1615
HAD-superfamily hydrolase, putative; Belongs to subfamily IA, variant 1.
  
    0.913
Your Current Organism:
Thermococcus gammatolerans
NCBI taxonomy Id: 593117
Other names: T. gammatolerans EJ3, Thermococcus gammatolerans EJ3, Thermococcus gammatolerans str. EJ3, Thermococcus gammatolerans strain EJ3
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