Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
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[Homology]
Score
ghmPGHMP kinase (ghmP); Catalyzes the condensation of 4-aminobenzoate (pABA) with 5- phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta- ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P). (322 aa)    
Predicted Functional Partners:
TGAM_1653
N-glycosylase/DNA lyase; DNA repair enzyme that is part of the base excision repair (BER) pathway; protects from oxidative damage by removing the major product of DNA oxidation, 8-oxoguanine (GO), from single- and double- stranded DNA substrates.
       0.914
TGAM_1655
Conserved hypothetical protein; 6 probable transmembrane helices predicted by modhmm.
 
     0.844
TGAM_1745
Dihydropteroate synthase-related protein.
 
     0.777
citG
ATP:dephospho-CoA triphosphoribosyl transferase (citG).
 
     0.774
TGAM_1654
Hypothetical protein; 1 probable transmembrane helix predicted by modhmm.
       0.634
TGAM_1651
Conserved hypothetical protein; Belongs to DUF20 family; 6 probable transmembrane helices predicted by modhmm.
 
     0.586
TGAM_0158
Conserved hypothetical protein; Belongs to DUF1464 family.
 
     0.582
TGAM_1656
ABC-type transport system, ATPase component, putative multidrug transporter.
       0.491
sppA
Signal peptide peptidase SppA (sppA); 1 probable transmembrane helix predicted by modhmm.
       0.488
TGAM_1650
Conserved hypothetical protein.
       0.488
Your Current Organism:
Thermococcus gammatolerans
NCBI taxonomy Id: 593117
Other names: T. gammatolerans EJ3, Thermococcus gammatolerans EJ3, Thermococcus gammatolerans str. EJ3, Thermococcus gammatolerans strain EJ3
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