Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
truAtRNA-pseudouridine synthase A (truA); Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs; Belongs to the tRNA pseudouridine synthase TruA family. (267 aa)    
Predicted Functional Partners:
truB
Centromere binding protein CBF5/pseudouridine synthase truB-like protein (truB); Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
 
 
 0.949
truD
tRNA pseudouridylate synthase D (TruD); Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs; Belongs to the pseudouridine synthase TruD family.
 
 
 0.915
pus10
RNA-binding protein, pseudouridine synthase family; Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.
  
  
 0.882
rpoD
DNA-directed RNA polymerase subunit D (rpoD); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoD/eukaryotic RPB3 RNA polymerase subunit family.
  
  
 0.853
ksgA
Ribosomal RNA adenine methylase transferase (Dimethyladenosine transferase) (ksgA); Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
 
  
 0.748
dpm1-2
Dolichol-phosphate mannosyltransferase (dpm1); 2 probable transmembrane helices predicted by modhmm.
  
    0.697
pheS
Phenylalanyl-tRNA synthetase, alpha subunit (pheS); Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
  
  
 0.680
trm1
N2,N2-dimethylguanosine tRNA methyltransferase (trm1); Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
  
 
 0.660
pheT
Phenylalanyl-tRNA synthetase, beta subunit (pheT_arch).
 
  
 0.659
TGAM_1801
Cobalt transport protein, cbiQ family; 2 probable transmembrane helices predicted by modhmm.
  
  
 0.657
Your Current Organism:
Thermococcus gammatolerans
NCBI taxonomy Id: 593117
Other names: T. gammatolerans EJ3, Thermococcus gammatolerans EJ3, Thermococcus gammatolerans str. EJ3, Thermococcus gammatolerans strain EJ3
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.