Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
pckGPhosphoenolpyruvate carboxykinase [GTP] (pckG); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. (625 aa)    
Predicted Functional Partners:
acdA-1
Acetyl-CoA synthetase (ADP forming), alpha chain (acdA).
     
 0.954
eno-1
Enolase (2-phosphoglycerate dehydratase) (2-phospho-D-glycerate hydro-lyase) (eno); Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
 
  
 0.953
pyk
Pyruvate kinase (pyk); Belongs to the pyruvate kinase family.
  
 
 0.938
pycB
Pyruvate carboxylase subunit B (pycB).
    
 0.937
eno-2
Enolase-related protein (eno).
 
  
 0.932
korA-1
2-ketoglutarate ferredoxin oxidoreductase, subunit alpha (korA).
   
 
 0.915
ppsA
Phosphoenolpyruvate synthase (pyruvate,water dikinase) (PEP synthase) (ppsA); Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family.
     
 0.910
mmdB
Methylmalonyl-CoA decarboxylase, beta chain (MmdB); 8 probable transmembrane helices predicted by modhmm.
    
  0.900
acdB-1
Acetyl-CoA synthetase (ADP forming), beta chain (acdB).
     
 0.888
korB-1
2-ketoglutarate ferredoxin oxidoreductase, subunit beta (korB).
   
 
 0.887
Your Current Organism:
Thermococcus gammatolerans
NCBI taxonomy Id: 593117
Other names: T. gammatolerans EJ3, Thermococcus gammatolerans EJ3, Thermococcus gammatolerans str. EJ3, Thermococcus gammatolerans strain EJ3
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.