Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ptpS-26-pyruvoyl tetrahydrobiopterin synthase (PTPS). (154 aa)    
Predicted Functional Partners:
queE
Radical SAM protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
 
 
 0.985
exsB
Transcription regulator, putative, ExsB family (ExsB); Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family.
 
  
 0.918
hisI
Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase (HisI); In the N-terminal section; belongs to the PRA-CH family.
     
 0.779
TGAM_1866
Carbohydrate kinase, putative, PfkB family.
       0.779
gyaR
Glyoxylate reductase (gyaR).
       0.768
TGAM_0571
DNA-Binding protein, putative; Contains Sigma3 and sigma4 domains of RNA polymerase sigma factors (SSF88659). DUF134 family; Belongs to the UPF0251 family.
       0.649
rumA-1
23S rRNA (uracil-5-)-methyltransferase (rumA); Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
       0.517
ptpS-1
6-pyruvoyl tetrahydrobiopterin synthase (ptpS).
  
     0.509
cysS
Cysteinyl-tRNA synthetase (cysS).
  
  
 0.478
TGAM_1869
Conserved hypothetical protein.
       0.433
Your Current Organism:
Thermococcus gammatolerans
NCBI taxonomy Id: 593117
Other names: T. gammatolerans EJ3, Thermococcus gammatolerans EJ3, Thermococcus gammatolerans str. EJ3, Thermococcus gammatolerans strain EJ3
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