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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pyrEOrotate phosphoribosyltransferase (pyrE); Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (189 aa)    
Predicted Functional Partners:
pyrF
Orotidine 5'-phosphate decarboxylase (pyrF); Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily.
 
 0.998
pyrD
Dihydroorotase dehydrogenase (pyrD); Catalyzes the conversion of dihydroorotate to orotate.
 
 0.997
pyrC
Dihydroorotase (pyrC); Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
 
  
 0.977
pyrB
Aspartate carbamoyltransferase, catalytic subunit (pyrB).
 
  
 0.972
pyrK
Dihydroorotate dehydrogenase electron transfer subunit (pyrK); Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).
  
 
 0.969
prs
Ribose-phosphate pyrophosphokinase (prs); Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P).
 
 
 0.901
TGAM_0001
Putative asparagine synthase, glutamine-hydrolyzing.
  
  
 0.751
asnB
Asparagine synthase (glutamine-hydrolyzing) (asnB).
  
  
 0.751
purD
Phosphoribosylamine--glycine ligase (purD).
 
  
 0.743
hisI
Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase (HisI); In the N-terminal section; belongs to the PRA-CH family.
     
 0.731
Your Current Organism:
Thermococcus gammatolerans
NCBI taxonomy Id: 593117
Other names: T. gammatolerans EJ3, Thermococcus gammatolerans EJ3, Thermococcus gammatolerans str. EJ3, Thermococcus gammatolerans strain EJ3
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