Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
TGAM_1901Membrane permease, stomatin-like protein; 1 probable transmembrane helix predicted by modhmm. (267 aa)    
Predicted Functional Partners:
nfeD
Membrane bound protease, putative, nfeD/ClpP- family (nfeD); 4 probable transmembrane helices predicted by modhmm.
 
  
 0.971
TGAM_1903
Conserved hypothetical protein.
       0.834
pyrE
Orotate phosphoribosyltransferase (pyrE); Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
  
 
 0.674
TGAM_1192
Base excision DNA repair protein, HhH-GPD superfamily.
  
    0.655
TGAM_1190
Conserved hypothetical protein.
       0.649
TGAM_1191
Conserved hypothetical protein.
       0.649
minD-1
Cell division ATPase MinD (minD).
       0.649
TGAM_1784
Conserved hypothetical protein; 1 probable transmembrane helix predicted by modhmm.
       0.649
pan
ATP-dependent 26S proteasome regulatory subunit P45 family; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP bindin [...]
   
 
 0.524
TGAM_1937
ATP binding protein, XPA-binding protein 1-like protein.
   
 0.520
Your Current Organism:
Thermococcus gammatolerans
NCBI taxonomy Id: 593117
Other names: T. gammatolerans EJ3, Thermococcus gammatolerans EJ3, Thermococcus gammatolerans str. EJ3, Thermococcus gammatolerans strain EJ3
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