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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TGAM_2018Nucleotide binding protein, putative, containing PIN domain. (129 aa)    
Predicted Functional Partners:
TGAM_2019
Hypothetical protein; Some similarity with PH1298 N term region.
       0.800
rtcA
RNA 3'-terminal phosphate cyclase (rtcA); Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
     
 0.654
TGAM_2084
Conserved hypothetical protein.
 
     0.632
TGAM_2085
Conserved hypothetical protein; Belongs to UPF0175 family.
 
     0.533
TGAM_2022
Metal-dependent phosphoesterase, putative.
       0.494
TGAM_2021
Conserved hypothetical protein; 1 probable transmembrane helix predicted by modhmm.
       0.490
TGAM_0156
Site-specific DNA-methyltransferase (cytosine-N(4)-specific).
 
     0.410
Your Current Organism:
Thermococcus gammatolerans
NCBI taxonomy Id: 593117
Other names: T. gammatolerans EJ3, Thermococcus gammatolerans EJ3, Thermococcus gammatolerans str. EJ3, Thermococcus gammatolerans strain EJ3
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