Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
rrp42p3'-5' exoribonuclease, exosome complex exonuclease 2, Rrp42p-like protein (Rrp42p); Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site. (273 aa)    
Predicted Functional Partners:
rrp41p
3'-5' exoribonuclease, exosome complex exonuclease 1, Rrp41p-like protein (Rrp41p); Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.
 
0.999
rrp4p
Exosome complex RNA-binding protein 1, Rrp4p-like protein (Rrp4p); Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.
 
 0.999
csl4
RNA-binding protein, containing S1 RNA binding domain; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.
  
 0.998
psmA
Peptidase T1A, 20S proteasome alpha-subunit (psmA); Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
 
  
 0.967
dnaG
Primase-related protein; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.
  
 
 0.963
TGAM_2038
Ribosome maturation protein SDO1; Shwachman-Bodian-Diamond syndrome (SBDS) related protein, possibly a translation elongation factor EFG/EF2.
 
  
 0.941
rps6E
SSU ribosomal protein S6E (rps6E); Belongs to the eukaryotic ribosomal protein eS6 family.
   
  0.923
rps4P
SSU ribosomal protein S4P (rps4P); One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
 
  0.922
TGAM_1424
RNA-binding protein, containing KH domain.
  
 0.919
nep1
Ribosome biogenesis protein NEP1-like protein; Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.
  
  0.902
Your Current Organism:
Thermococcus gammatolerans
NCBI taxonomy Id: 593117
Other names: T. gammatolerans EJ3, Thermococcus gammatolerans EJ3, Thermococcus gammatolerans str. EJ3, Thermococcus gammatolerans strain EJ3
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