Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
TGAM_2041Hit histidine triad protein (hit). (196 aa)    
Predicted Functional Partners:
hit
Histidine triad (HIT) protein (hit).
  
  
 
0.908
TGAM_2040
Conserved hypothetical protein; 2 probable transmembrane helices predicted by modhmm.
       0.843
psmA
Peptidase T1A, 20S proteasome alpha-subunit (psmA); Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
  
    0.826
TGAM_2038
Ribosome maturation protein SDO1; Shwachman-Bodian-Diamond syndrome (SBDS) related protein, possibly a translation elongation factor EFG/EF2.
  
    0.788
rrp4p
Exosome complex RNA-binding protein 1, Rrp4p-like protein (Rrp4p); Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.
       0.783
rrp42p
3'-5' exoribonuclease, exosome complex exonuclease 2, Rrp42p-like protein (Rrp42p); Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.
       0.762
rrp41p
3'-5' exoribonuclease, exosome complex exonuclease 1, Rrp41p-like protein (Rrp41p); Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.
       0.762
hisI
Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase (HisI); In the N-terminal section; belongs to the PRA-CH family.
  
    0.527
glnA
Glutamine synthetase (glnA).
  
   0.523
npdA
NAD-dependent protein deacetylase, Sir2 family (npdA); Belongs to the sirtuin family. Class III subfamily.
  
 
  0.483
Your Current Organism:
Thermococcus gammatolerans
NCBI taxonomy Id: 593117
Other names: T. gammatolerans EJ3, Thermococcus gammatolerans EJ3, Thermococcus gammatolerans str. EJ3, Thermococcus gammatolerans strain EJ3
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