Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
pyrIAspartate carbamoyltransferase, regulatory subunit (pyrI); Involved in allosteric regulation of aspartate carbamoyltransferase. (151 aa)    
Predicted Functional Partners:
pyrB
Aspartate carbamoyltransferase, catalytic subunit (pyrB).
 0.999
pyrC
Dihydroorotase (pyrC); Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
 
  
 0.944
purA
Adenylosuccinate synthetase (purA); Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
    
 0.942
pyrF
Orotidine 5'-phosphate decarboxylase (pyrF); Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily.
  
 
 0.938
TGAM_2143
Asparagine synthetase related protein.
 
  
  0.915
TGAM_0001
Putative asparagine synthase, glutamine-hydrolyzing.
    
  0.904
asnB
Asparagine synthase (glutamine-hydrolyzing) (asnB).
    
  0.904
nadB
L-aspartate oxidase (quinolinate synthetase B) (nadB); Catalyzes the oxidation of L-aspartate to iminoaspartate.
     
  0.900
racD-1
Aspartate racemase (racD).
    
  0.900
racD-2
Aspartate racemase (racD).
    
  0.900
Your Current Organism:
Thermococcus gammatolerans
NCBI taxonomy Id: 593117
Other names: T. gammatolerans EJ3, Thermococcus gammatolerans EJ3, Thermococcus gammatolerans str. EJ3, Thermococcus gammatolerans strain EJ3
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