node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SFS31668.1 | guaA | SAMN04488006_0596 | SAMN04488006_1799 | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. | 0.954 |
SFS31668.1 | guaB | SAMN04488006_0596 | SAMN04488006_0702 | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.877 |
SFS31668.1 | murD | SAMN04488006_0596 | SAMN04488006_1856 | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.489 |
SFS31668.1 | murI | SAMN04488006_0596 | SAMN04488006_1569 | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.923 |
SFS40604.1 | SFS40631.1 | SAMN04488006_1124 | SAMN04488006_1126 | Glutamate dehydrogenase (NADP+); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Glutamate dehydrogenase (NADP+); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.772 |
SFS40604.1 | glsA | SAMN04488006_1124 | SAMN04488006_0880 | Glutamate dehydrogenase (NADP+); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | L-glutaminase; Belongs to the glutaminase family. | 0.689 |
SFS40604.1 | murI | SAMN04488006_1124 | SAMN04488006_1569 | Glutamate dehydrogenase (NADP+); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.705 |
SFS40604.1 | purL | SAMN04488006_1124 | SAMN04488006_0032 | Glutamate dehydrogenase (NADP+); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.701 |
SFS40631.1 | SFS40604.1 | SAMN04488006_1126 | SAMN04488006_1124 | Glutamate dehydrogenase (NADP+); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Glutamate dehydrogenase (NADP+); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.772 |
SFS40631.1 | glsA | SAMN04488006_1126 | SAMN04488006_0880 | Glutamate dehydrogenase (NADP+); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | L-glutaminase; Belongs to the glutaminase family. | 0.689 |
SFS40631.1 | murI | SAMN04488006_1126 | SAMN04488006_1569 | Glutamate dehydrogenase (NADP+); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.705 |
SFS40631.1 | purL | SAMN04488006_1126 | SAMN04488006_0032 | Glutamate dehydrogenase (NADP+); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.701 |
SFS48332.1 | murI | SAMN04488006_1568 | SAMN04488006_1569 | Periplasmic chaperone for outer membrane proteins Skp. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.612 |
glsA | SFS40604.1 | SAMN04488006_0880 | SAMN04488006_1124 | L-glutaminase; Belongs to the glutaminase family. | Glutamate dehydrogenase (NADP+); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.689 |
glsA | SFS40631.1 | SAMN04488006_0880 | SAMN04488006_1126 | L-glutaminase; Belongs to the glutaminase family. | Glutamate dehydrogenase (NADP+); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.689 |
glsA | murI | SAMN04488006_0880 | SAMN04488006_1569 | L-glutaminase; Belongs to the glutaminase family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.873 |
guaA | SFS31668.1 | SAMN04488006_1799 | SAMN04488006_0596 | GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.954 |
guaA | guaB | SAMN04488006_1799 | SAMN04488006_0702 | GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.999 |
guaA | murD | SAMN04488006_1799 | SAMN04488006_1856 | GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. | UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.400 |
guaA | murI | SAMN04488006_1799 | SAMN04488006_1569 | GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.800 |