dnaK protein (Fibrobacter succinogenes) - STRING interaction network

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Score

dnaK

Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. (633 aa)

Predicted Functional Partners:

dnaJ

0.999

grpE

0.997

htpG

0.991

groEL

0.958

groES

0.948

clpB

0.942

clpC

0.942

FSU_2334

0.924

rplP

0.854

hepA

0.832

Your Current Organism:

Fibrobacter succinogenes

NCBI taxonomy Id: 59374
Other names: F. succinogenes subsp. succinogenes S85, Fibrobacter succinogenes S85, Fibrobacter succinogenes subsp. succinogenes S85

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FSU_2334	clpB	FSU_2334	FSU_2824	Putative chaperone protein DnaK; Identified by match to protein family HMM PF00012.	Protein ClpB; Identified by similarity to SP:P03815; match to protein family HMM PF00004; match to protein family HMM PF02861; match to protein family HMM PF07724; match to protein family HMM PF07728; Belongs to the ClpA/ClpB family.	0.942
FSU_2334	clpC	FSU_2334	FSU_3208	Putative chaperone protein DnaK; Identified by match to protein family HMM PF00012.	ATP-dependent Clp protease, ATP-binding subunit ClpC; Identified by similarity to SP:P37571; match to protein family HMM PF00004; match to protein family HMM PF02151; match to protein family HMM PF02861; match to protein family HMM PF07724; match to protein family HMM PF07728; Belongs to the ClpA/ClpB family.	0.942
FSU_2334	dnaJ	FSU_2334	FSU_0184	Putative chaperone protein DnaK; Identified by match to protein family HMM PF00012.	Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]	0.998
FSU_2334	dnaK	FSU_2334	FSU_0185	Putative chaperone protein DnaK; Identified by match to protein family HMM PF00012.	Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.924
FSU_2334	groEL	FSU_2334	FSU_0456	Putative chaperone protein DnaK; Identified by match to protein family HMM PF00012.	Chaperonin, 60 kDa; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.	0.894
FSU_2334	groES	FSU_2334	FSU_0455	Putative chaperone protein DnaK; Identified by match to protein family HMM PF00012.	Chaperonin, 10 kDa; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.	0.873
FSU_2334	grpE	FSU_2334	FSU_0193	Putative chaperone protein DnaK; Identified by match to protein family HMM PF00012.	GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]	0.992
FSU_2334	hepA	FSU_2334	FSU_0598	Putative chaperone protein DnaK; Identified by match to protein family HMM PF00012.	RNA polymerase-associated protein HepA; Identified by similarity to SP:P23852; match to protein family HMM PF00176; match to protein family HMM PF00271.	0.832
FSU_2334	htpG	FSU_2334	FSU_0677	Putative chaperone protein DnaK; Identified by match to protein family HMM PF00012.	Heat shock protein HtpG; Molecular chaperone. Has ATPase activity.	0.991
FSU_2334	rplP	FSU_2334	FSU_1883	Putative chaperone protein DnaK; Identified by match to protein family HMM PF00012.	Ribosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family.	0.854
clpB	FSU_2334	FSU_2824	FSU_2334	Protein ClpB; Identified by similarity to SP:P03815; match to protein family HMM PF00004; match to protein family HMM PF02861; match to protein family HMM PF07724; match to protein family HMM PF07728; Belongs to the ClpA/ClpB family.	Putative chaperone protein DnaK; Identified by match to protein family HMM PF00012.	0.942
clpB	dnaJ	FSU_2824	FSU_0184	Protein ClpB; Identified by similarity to SP:P03815; match to protein family HMM PF00004; match to protein family HMM PF02861; match to protein family HMM PF07724; match to protein family HMM PF07728; Belongs to the ClpA/ClpB family.	Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]	0.830
clpB	dnaK	FSU_2824	FSU_0185	Protein ClpB; Identified by similarity to SP:P03815; match to protein family HMM PF00004; match to protein family HMM PF02861; match to protein family HMM PF07724; match to protein family HMM PF07728; Belongs to the ClpA/ClpB family.	Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.942
clpB	groEL	FSU_2824	FSU_0456	Protein ClpB; Identified by similarity to SP:P03815; match to protein family HMM PF00004; match to protein family HMM PF02861; match to protein family HMM PF07724; match to protein family HMM PF07728; Belongs to the ClpA/ClpB family.	Chaperonin, 60 kDa; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.	0.620
clpB	groES	FSU_2824	FSU_0455	Protein ClpB; Identified by similarity to SP:P03815; match to protein family HMM PF00004; match to protein family HMM PF02861; match to protein family HMM PF07724; match to protein family HMM PF07728; Belongs to the ClpA/ClpB family.	Chaperonin, 10 kDa; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.	0.623
clpB	grpE	FSU_2824	FSU_0193	Protein ClpB; Identified by similarity to SP:P03815; match to protein family HMM PF00004; match to protein family HMM PF02861; match to protein family HMM PF07724; match to protein family HMM PF07728; Belongs to the ClpA/ClpB family.	GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]	0.854
clpB	htpG	FSU_2824	FSU_0677	Protein ClpB; Identified by similarity to SP:P03815; match to protein family HMM PF00004; match to protein family HMM PF02861; match to protein family HMM PF07724; match to protein family HMM PF07728; Belongs to the ClpA/ClpB family.	Heat shock protein HtpG; Molecular chaperone. Has ATPase activity.	0.802
clpC	FSU_2334	FSU_3208	FSU_2334	ATP-dependent Clp protease, ATP-binding subunit ClpC; Identified by similarity to SP:P37571; match to protein family HMM PF00004; match to protein family HMM PF02151; match to protein family HMM PF02861; match to protein family HMM PF07724; match to protein family HMM PF07728; Belongs to the ClpA/ClpB family.	Putative chaperone protein DnaK; Identified by match to protein family HMM PF00012.	0.942
clpC	dnaJ	FSU_3208	FSU_0184	ATP-dependent Clp protease, ATP-binding subunit ClpC; Identified by similarity to SP:P37571; match to protein family HMM PF00004; match to protein family HMM PF02151; match to protein family HMM PF02861; match to protein family HMM PF07724; match to protein family HMM PF07728; Belongs to the ClpA/ClpB family.	Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]	0.830
clpC	dnaK	FSU_3208	FSU_0185	ATP-dependent Clp protease, ATP-binding subunit ClpC; Identified by similarity to SP:P37571; match to protein family HMM PF00004; match to protein family HMM PF02151; match to protein family HMM PF02861; match to protein family HMM PF07724; match to protein family HMM PF07728; Belongs to the ClpA/ClpB family.	Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.942