STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hemDXPorphyrin biosynthesis protein HemDX; Also 4.2.1.75; identified by similarity to GB:AAK00606.1; match to protein family HMM PF00590; match to protein family HMM PF02602; match to protein family HMM TIGR01469. (525 aa)    
Predicted Functional Partners:
hemB
Porphobilinogen synthase; Identified by similarity to SP:P30950; match to protein family HMM PF00490; Belongs to the ALAD family.
 0.999
FSU_0300
Siroheme synthase; Identified by match to protein family HMM PF01903; match to protein family HMM TIGR01470.
 
 0.999
hemC
Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
 0.999
hemL
Glutamate-1-semialdehyde-2,1-aminomutase; Identified by match to protein family HMM PF00202; match to protein family HMM TIGR00713.
 
 
 0.964
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
  
 0.925
FSU_2156
Phosphoadenosine phosphosulfate reductase domain protein; Identified by match to protein family HMM PF01507.
  
  
 0.735
cysD
Sulfate adenylyltransferase, subunit 2; Identified by similarity to SP:P21156; match to protein family HMM PF01507; match to protein family HMM TIGR02039.
  
  
 0.730
FSU_1969
Putative TRK system potassium uptake protein TrkA; Identified by similarity to GB:BAA31234.1; match to protein family HMM PF02080; match to protein family HMM PF02254.
  
  
 0.723
FSU_0305
nirD domain protein; Identified by similarity to PIR:G83581.
 
 
 0.712
FSU_2649
Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family.
  
 
 0.698
Your Current Organism:
Fibrobacter succinogenes
NCBI taxonomy Id: 59374
Other names: F. succinogenes subsp. succinogenes S85, Fibrobacter succinogenes S85, Fibrobacter succinogenes subsp. succinogenes S85
Server load: low (28%) [HD]