STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
metXWHomoserine O-acetyltransferase/methionine biosynthesis protein; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (637 aa)    
Predicted Functional Partners:
FSU_0558
O-acetylhomoserine sulfhydrylase; Identified by similarity to PIR:T44655; match to protein family HMM PF01053; match to protein family HMM TIGR01326.
 
 0.971
FSU_1526
O-acetylhomoserine sulfhydrylase; Identified by similarity to PIR:T44655; match to protein family HMM PF01053; match to protein family HMM PF01212; match to protein family HMM TIGR01326.
 
 0.970
FSU_0565
Cys/Met metabolism PLP-dependent enzyme; Identified by match to protein family HMM PF01053.
 
 0.969
FSU_1584
O-acetylhomoserine sulfhydrylase; Identified by similarity to PIR:T44655; match to protein family HMM PF01053; match to protein family HMM TIGR01326.
 
 0.968
hom
Homoserine dehydrogenase; Identified by similarity to SP:P19582; match to protein family HMM PF00742; match to protein family HMM PF01842; match to protein family HMM PF03447.
 
 0.964
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
    
 0.853
metH
5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
  
  
 0.844
FSU_0852
Putative CDP-diacylglycerol--serine O-phosphatidyltransferase; Identified by similarity to SP:Q48269; match to protein family HMM PF01066; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
 
  
  0.837
thrH
Phosphoserine phosphatase/homoserine phosphotransferase protein; Identified by similarity to GB:CAA07580.1; match to protein family HMM PF00702; match to protein family HMM TIGR02137.
  
 0.822
trpB
Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
     
 0.815
Your Current Organism:
Fibrobacter succinogenes
NCBI taxonomy Id: 59374
Other names: F. succinogenes subsp. succinogenes S85, Fibrobacter succinogenes S85, Fibrobacter succinogenes subsp. succinogenes S85
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