| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| FSU_0937 | FSU_0971 | FSU_0937 | FSU_0971 | Putative DNA topoisomerase IV, A subunit; Identified by match to protein family HMM PF00521. | Putative DNA topoisomerase IV, B subunit; Identified by match to protein family HMM PF00204; match to protein family HMM PF02518. | 0.987 |
| FSU_0937 | FSU_1312 | FSU_0937 | FSU_1312 | Putative DNA topoisomerase IV, A subunit; Identified by match to protein family HMM PF00521. | Hypothetical protein; Identified by glimmer; putative. | 0.945 |
| FSU_0937 | gyrA | FSU_0937 | FSU_0778 | Putative DNA topoisomerase IV, A subunit; Identified by match to protein family HMM PF00521. | DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.657 |
| FSU_0937 | metS | FSU_0937 | FSU_0104 | Putative DNA topoisomerase IV, A subunit; Identified by match to protein family HMM PF00521. | methionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily. | 0.622 |
| FSU_0937 | nusA | FSU_0937 | FSU_2842 | Putative DNA topoisomerase IV, A subunit; Identified by match to protein family HMM PF00521. | N utilization substance protein A; Participates in both transcription termination and antitermination. | 0.535 |
| FSU_0971 | FSU_0937 | FSU_0971 | FSU_0937 | Putative DNA topoisomerase IV, B subunit; Identified by match to protein family HMM PF00204; match to protein family HMM PF02518. | Putative DNA topoisomerase IV, A subunit; Identified by match to protein family HMM PF00521. | 0.987 |
| FSU_0971 | gyrA | FSU_0971 | FSU_0778 | Putative DNA topoisomerase IV, B subunit; Identified by match to protein family HMM PF00204; match to protein family HMM PF02518. | DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.994 |
| FSU_0971 | polA | FSU_0971 | FSU_1227 | Putative DNA topoisomerase IV, B subunit; Identified by match to protein family HMM PF00204; match to protein family HMM PF02518. | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.448 |
| FSU_1312 | FSU_0937 | FSU_1312 | FSU_0937 | Hypothetical protein; Identified by glimmer; putative. | Putative DNA topoisomerase IV, A subunit; Identified by match to protein family HMM PF00521. | 0.945 |
| FSU_1312 | gyrA | FSU_1312 | FSU_0778 | Hypothetical protein; Identified by glimmer; putative. | DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.945 |
| FSU_1312 | polA | FSU_1312 | FSU_1227 | Hypothetical protein; Identified by glimmer; putative. | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.448 |
| aroKB | gyrA | FSU_2787 | FSU_0778 | Shikimate kinase/3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.624 |
| aroKB | metS | FSU_2787 | FSU_0104 | Shikimate kinase/3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | methionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily. | 0.423 |
| aroKB | nusA | FSU_2787 | FSU_2842 | Shikimate kinase/3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | N utilization substance protein A; Participates in both transcription termination and antitermination. | 0.406 |
| folD | gyrA | FSU_1983 | FSU_0778 | Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.766 |
| folD | polA | FSU_1983 | FSU_1227 | Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.420 |
| gyrA | FSU_0937 | FSU_0778 | FSU_0937 | DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | Putative DNA topoisomerase IV, A subunit; Identified by match to protein family HMM PF00521. | 0.657 |
| gyrA | FSU_0971 | FSU_0778 | FSU_0971 | DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | Putative DNA topoisomerase IV, B subunit; Identified by match to protein family HMM PF00204; match to protein family HMM PF02518. | 0.994 |
| gyrA | FSU_1312 | FSU_0778 | FSU_1312 | DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | Hypothetical protein; Identified by glimmer; putative. | 0.945 |
| gyrA | aroKB | FSU_0778 | FSU_2787 | DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | Shikimate kinase/3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | 0.624 |
