STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
thiCThiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (538 aa)    
Predicted Functional Partners:
thiD
Phosphomethylpyrimidine kinase; Identified by similarity to SP:P76422; match to protein family HMM PF08543.
 
 
 0.989
thiE
Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
 
  
 0.981
thiG
Thiazole biosynthesis protein ThiG; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
 
  
 0.967
thiH
Thiazole biosynthesis protein ThiH; Identified by similarity to SP:P30140; match to protein family HMM PF04055; match to protein family HMM PF06968; match to protein family HMM TIGR02351.
 
  
 0.930
FSU_0144
Hypothetical protein; Identified by glimmer; putative.
  
  
 0.821
purM
Phosphoribosylformylglycinamidine cyclo-ligase; Identified by similarity to SP:P12043; match to protein family HMM PF00586; match to protein family HMM PF02769; match to protein family HMM TIGR00878.
     
 0.808
thiS_1
Thiamine biosynthesis protein ThiS; Identified by match to protein family HMM PF02597; match to protein family HMM TIGR01683.
  
  
 0.798
thiS_2
Thiamine biosynthesis protein ThiS; Identified by match to protein family HMM PF02597; match to protein family HMM TIGR01683.
  
  
 0.798
FSU_2467
Menaquinone biosynthesis protein, SCO4550 family; Identified by match to protein family HMM PF04055; match to protein family HMM TIGR03699.
  
  
 0.773
FSU_2870
Radical SAM domain protein; Identified by match to protein family HMM PF04055; match to protein family HMM TIGR00423; match to protein family HMM TIGR03700.
  
  
 0.773
Your Current Organism:
Fibrobacter succinogenes
NCBI taxonomy Id: 59374
Other names: F. succinogenes subsp. succinogenes S85, Fibrobacter succinogenes S85, Fibrobacter succinogenes subsp. succinogenes S85
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.