node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FSU_0109 | apt | FSU_0109 | FSU_0263 | Identified by match to protein family HMM PF00149; match to protein family HMM PF02872; Belongs to the 5'-nucleotidase family. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.907 |
FSU_0109 | gmk | FSU_0109 | FSU_0818 | Identified by match to protein family HMM PF00149; match to protein family HMM PF02872; Belongs to the 5'-nucleotidase family. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.901 |
FSU_0109 | guaA | FSU_0109 | FSU_0249 | Identified by match to protein family HMM PF00149; match to protein family HMM PF02872; Belongs to the 5'-nucleotidase family. | GMP synthase; Identified by similarity to SP:P04079; match to protein family HMM PF00117; match to protein family HMM PF00958; match to protein family HMM TIGR00888. | 0.914 |
FSU_0109 | guaB | FSU_0109 | FSU_3016 | Identified by match to protein family HMM PF00149; match to protein family HMM PF02872; Belongs to the 5'-nucleotidase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.909 |
FSU_0109 | hpt | FSU_0109 | FSU_1170 | Identified by match to protein family HMM PF00149; match to protein family HMM PF02872; Belongs to the 5'-nucleotidase family. | Hypoxanthine phosphoribosyltransferase; Identified by similarity to SP:P36766; match to protein family HMM PF00156; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.903 |
FSU_0109 | rdgB | FSU_0109 | FSU_3140 | Identified by match to protein family HMM PF00149; match to protein family HMM PF02872; Belongs to the 5'-nucleotidase family. | Non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.900 |
FSU_0109 | surE | FSU_0109 | FSU_0779 | Identified by match to protein family HMM PF00149; match to protein family HMM PF02872; Belongs to the 5'-nucleotidase family. | Acid phosphatase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.908 |
FSU_0109 | xpt | FSU_0109 | FSU_2152 | Identified by match to protein family HMM PF00149; match to protein family HMM PF02872; Belongs to the 5'-nucleotidase family. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.907 |
FSU_2151 | apt | FSU_2151 | FSU_0263 | Xanthine-uracil permease; Identified by match to protein family HMM PF00860; match to protein family HMM PF03594; match to protein family HMM TIGR00801; match to protein family HMM TIGR03173. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.418 |
FSU_2151 | guaA | FSU_2151 | FSU_0249 | Xanthine-uracil permease; Identified by match to protein family HMM PF00860; match to protein family HMM PF03594; match to protein family HMM TIGR00801; match to protein family HMM TIGR03173. | GMP synthase; Identified by similarity to SP:P04079; match to protein family HMM PF00117; match to protein family HMM PF00958; match to protein family HMM TIGR00888. | 0.457 |
FSU_2151 | xpt | FSU_2151 | FSU_2152 | Xanthine-uracil permease; Identified by match to protein family HMM PF00860; match to protein family HMM PF03594; match to protein family HMM TIGR00801; match to protein family HMM TIGR03173. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.977 |
FSU_3137 | apt | FSU_3137 | FSU_0263 | Cytidine/deoxycytidylate deaminase zinc-binding domain protein; Identified by match to protein family HMM PF00383. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.902 |
FSU_3137 | hpt | FSU_3137 | FSU_1170 | Cytidine/deoxycytidylate deaminase zinc-binding domain protein; Identified by match to protein family HMM PF00383. | Hypoxanthine phosphoribosyltransferase; Identified by similarity to SP:P36766; match to protein family HMM PF00156; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.904 |
FSU_3137 | xpt | FSU_3137 | FSU_2152 | Cytidine/deoxycytidylate deaminase zinc-binding domain protein; Identified by match to protein family HMM PF00383. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.969 |
apt | FSU_0109 | FSU_0263 | FSU_0109 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Identified by match to protein family HMM PF00149; match to protein family HMM PF02872; Belongs to the 5'-nucleotidase family. | 0.907 |
apt | FSU_2151 | FSU_0263 | FSU_2151 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Xanthine-uracil permease; Identified by match to protein family HMM PF00860; match to protein family HMM PF03594; match to protein family HMM TIGR00801; match to protein family HMM TIGR03173. | 0.418 |
apt | FSU_3137 | FSU_0263 | FSU_3137 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Cytidine/deoxycytidylate deaminase zinc-binding domain protein; Identified by match to protein family HMM PF00383. | 0.902 |
apt | gmk | FSU_0263 | FSU_0818 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.950 |
apt | guaA | FSU_0263 | FSU_0249 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP synthase; Identified by similarity to SP:P04079; match to protein family HMM PF00117; match to protein family HMM PF00958; match to protein family HMM TIGR00888. | 0.989 |
apt | guaB | FSU_0263 | FSU_3016 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.417 |