| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| glyA | hom | FSU_3049 | FSU_2798 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Homoserine dehydrogenase; Identified by similarity to SP:P19582; match to protein family HMM PF00742; match to protein family HMM PF01842; match to protein family HMM PF03447. | 0.600 |
| glyA | metH | FSU_3049 | FSU_1627 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.742 |
| glyA | serC | FSU_3049 | FSU_1007 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Phosphoserine transaminase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. | 0.556 |
| glyA | thrH | FSU_3049 | FSU_2899 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Phosphoserine phosphatase/homoserine phosphotransferase protein; Identified by similarity to GB:CAA07580.1; match to protein family HMM PF00702; match to protein family HMM TIGR02137. | 0.751 |
| glyA | trpCF | FSU_3049 | FSU_0580 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Indole-3-glycerol phosphate synthase/N-(5'-phosphoribosyl)anthranilate isomerase; Identified by similarity to SP:O25867; match to protein family HMM PF00218; match to protein family HMM PF00697; Belongs to the TrpF family. | 0.693 |
| hisA | hisF | FSU_2783 | FSU_2822 | 1-(5-phosphoribosyl)-5-((5'-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase; Identified by similarity to SP:P40545; match to protein family HMM PF00977; match to protein family HMM TIGR02129; Belongs to the HisA/HisF family. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.978 |
| hisA | hisH | FSU_2783 | FSU_1063 | 1-(5-phosphoribosyl)-5-((5'-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase; Identified by similarity to SP:P40545; match to protein family HMM PF00977; match to protein family HMM TIGR02129; Belongs to the HisA/HisF family. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.978 |
| hisA | hisI | FSU_2783 | FSU_0317 | 1-(5-phosphoribosyl)-5-((5'-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase; Identified by similarity to SP:P40545; match to protein family HMM PF00977; match to protein family HMM TIGR02129; Belongs to the HisA/HisF family. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.978 |
| hisA | thrH | FSU_2783 | FSU_2899 | 1-(5-phosphoribosyl)-5-((5'-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase; Identified by similarity to SP:P40545; match to protein family HMM PF00977; match to protein family HMM TIGR02129; Belongs to the HisA/HisF family. | Phosphoserine phosphatase/homoserine phosphotransferase protein; Identified by similarity to GB:CAA07580.1; match to protein family HMM PF00702; match to protein family HMM TIGR02137. | 0.707 |
| hisA | trpCF | FSU_2783 | FSU_0580 | 1-(5-phosphoribosyl)-5-((5'-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase; Identified by similarity to SP:P40545; match to protein family HMM PF00977; match to protein family HMM TIGR02129; Belongs to the HisA/HisF family. | Indole-3-glycerol phosphate synthase/N-(5'-phosphoribosyl)anthranilate isomerase; Identified by similarity to SP:O25867; match to protein family HMM PF00218; match to protein family HMM PF00697; Belongs to the TrpF family. | 0.782 |
| hisF | hisA | FSU_2822 | FSU_2783 | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 1-(5-phosphoribosyl)-5-((5'-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase; Identified by similarity to SP:P40545; match to protein family HMM PF00977; match to protein family HMM TIGR02129; Belongs to the HisA/HisF family. | 0.978 |
| hisF | hisH | FSU_2822 | FSU_1063 | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
| hisF | hisI | FSU_2822 | FSU_0317 | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.998 |
| hisF | thrH | FSU_2822 | FSU_2899 | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | Phosphoserine phosphatase/homoserine phosphotransferase protein; Identified by similarity to GB:CAA07580.1; match to protein family HMM PF00702; match to protein family HMM TIGR02137. | 0.800 |
| hisF | trpCF | FSU_2822 | FSU_0580 | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | Indole-3-glycerol phosphate synthase/N-(5'-phosphoribosyl)anthranilate isomerase; Identified by similarity to SP:O25867; match to protein family HMM PF00218; match to protein family HMM PF00697; Belongs to the TrpF family. | 0.506 |
| hisH | hisA | FSU_1063 | FSU_2783 | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 1-(5-phosphoribosyl)-5-((5'-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase; Identified by similarity to SP:P40545; match to protein family HMM PF00977; match to protein family HMM TIGR02129; Belongs to the HisA/HisF family. | 0.978 |
| hisH | hisF | FSU_1063 | FSU_2822 | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
| hisH | hisI | FSU_1063 | FSU_0317 | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.995 |
| hisH | thrC | FSU_1063 | FSU_1158 | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. | 0.642 |
| hisH | thrH | FSU_1063 | FSU_2899 | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | Phosphoserine phosphatase/homoserine phosphotransferase protein; Identified by similarity to GB:CAA07580.1; match to protein family HMM PF00702; match to protein family HMM TIGR02137. | 0.718 |
