| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| FSU_0130 | FSU_1002 | FSU_0130 | FSU_1002 | Putative phosphoribosylaminoimidazolecarboxamide formyltransferase; Identified by similarity to SP:P15639; match to protein family HMM PF01808. | Putative 5,10-methylenetetrahydrofolate reductase; Identified by similarity to GB:AAF64321.1; match to protein family HMM PF02219; Belongs to the methylenetetrahydrofolate reductase family. | 0.597 |
| FSU_0130 | FSU_3238 | FSU_0130 | FSU_3238 | Putative phosphoribosylaminoimidazolecarboxamide formyltransferase; Identified by similarity to SP:P15639; match to protein family HMM PF01808. | purD domain protein; Identified by similarity to GB:CAA04374.1; match to protein family HMM PF01071; match to protein family HMM PF02222; match to protein family HMM PF02655. | 0.905 |
| FSU_0130 | folD | FSU_0130 | FSU_1983 | Putative phosphoribosylaminoimidazolecarboxamide formyltransferase; Identified by similarity to SP:P15639; match to protein family HMM PF01808. | Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.827 |
| FSU_0130 | glyA | FSU_0130 | FSU_3049 | Putative phosphoribosylaminoimidazolecarboxamide formyltransferase; Identified by similarity to SP:P15639; match to protein family HMM PF01808. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.944 |
| FSU_0130 | purA | FSU_0130 | FSU_2115 | Putative phosphoribosylaminoimidazolecarboxamide formyltransferase; Identified by similarity to SP:P15639; match to protein family HMM PF01808. | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.901 |
| FSU_0130 | purB | FSU_0130 | FSU_0110 | Putative phosphoribosylaminoimidazolecarboxamide formyltransferase; Identified by similarity to SP:P15639; match to protein family HMM PF01808. | Adenylosuccinate lyase; Identified by match to protein family HMM PF00206; match to protein family HMM TIGR00928; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.958 |
| FSU_0130 | purC | FSU_0130 | FSU_0618 | Putative phosphoribosylaminoimidazolecarboxamide formyltransferase; Identified by similarity to SP:P15639; match to protein family HMM PF01808. | Phosphoribosylaminoimidazolesuccinocarboxamide synthase; Identified by match to protein family HMM PF01259; match to protein family HMM TIGR00081; Belongs to the SAICAR synthetase family. | 0.983 |
| FSU_0130 | purD | FSU_0130 | FSU_2374 | Putative phosphoribosylaminoimidazolecarboxamide formyltransferase; Identified by similarity to SP:P15639; match to protein family HMM PF01808. | Phosphoribosylamine--glycine ligase; Identified by similarity to SP:P15640; match to protein family HMM PF01071; match to protein family HMM PF02843; match to protein family HMM PF02844; match to protein family HMM TIGR00877; Belongs to the GARS family. | 0.969 |
| FSU_0130 | purL | FSU_0130 | FSU_0356 | Putative phosphoribosylaminoimidazolecarboxamide formyltransferase; Identified by similarity to SP:P15639; match to protein family HMM PF01808. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.997 |
| FSU_0130 | purU | FSU_0130 | FSU_0882 | Putative phosphoribosylaminoimidazolecarboxamide formyltransferase; Identified by similarity to SP:P15639; match to protein family HMM PF01808. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.557 |
| FSU_1002 | FSU_0130 | FSU_1002 | FSU_0130 | Putative 5,10-methylenetetrahydrofolate reductase; Identified by similarity to GB:AAF64321.1; match to protein family HMM PF02219; Belongs to the methylenetetrahydrofolate reductase family. | Putative phosphoribosylaminoimidazolecarboxamide formyltransferase; Identified by similarity to SP:P15639; match to protein family HMM PF01808. | 0.597 |
| FSU_1002 | folD | FSU_1002 | FSU_1983 | Putative 5,10-methylenetetrahydrofolate reductase; Identified by similarity to GB:AAF64321.1; match to protein family HMM PF02219; Belongs to the methylenetetrahydrofolate reductase family. | Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.593 |
| FSU_1002 | glyA | FSU_1002 | FSU_3049 | Putative 5,10-methylenetetrahydrofolate reductase; Identified by similarity to GB:AAF64321.1; match to protein family HMM PF02219; Belongs to the methylenetetrahydrofolate reductase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.827 |
| FSU_1002 | purU | FSU_1002 | FSU_0882 | Putative 5,10-methylenetetrahydrofolate reductase; Identified by similarity to GB:AAF64321.1; match to protein family HMM PF02219; Belongs to the methylenetetrahydrofolate reductase family. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.589 |
| FSU_3238 | FSU_0130 | FSU_3238 | FSU_0130 | purD domain protein; Identified by similarity to GB:CAA04374.1; match to protein family HMM PF01071; match to protein family HMM PF02222; match to protein family HMM PF02655. | Putative phosphoribosylaminoimidazolecarboxamide formyltransferase; Identified by similarity to SP:P15639; match to protein family HMM PF01808. | 0.905 |
| FSU_3238 | folD | FSU_3238 | FSU_1983 | purD domain protein; Identified by similarity to GB:CAA04374.1; match to protein family HMM PF01071; match to protein family HMM PF02222; match to protein family HMM PF02655. | Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.600 |
| FSU_3238 | glyA | FSU_3238 | FSU_3049 | purD domain protein; Identified by similarity to GB:CAA04374.1; match to protein family HMM PF01071; match to protein family HMM PF02222; match to protein family HMM PF02655. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.818 |
| FSU_3238 | purA | FSU_3238 | FSU_2115 | purD domain protein; Identified by similarity to GB:CAA04374.1; match to protein family HMM PF01071; match to protein family HMM PF02222; match to protein family HMM PF02655. | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.654 |
| FSU_3238 | purB | FSU_3238 | FSU_0110 | purD domain protein; Identified by similarity to GB:CAA04374.1; match to protein family HMM PF01071; match to protein family HMM PF02222; match to protein family HMM PF02655. | Adenylosuccinate lyase; Identified by match to protein family HMM PF00206; match to protein family HMM TIGR00928; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.979 |
| FSU_3238 | purC | FSU_3238 | FSU_0618 | purD domain protein; Identified by similarity to GB:CAA04374.1; match to protein family HMM PF01071; match to protein family HMM PF02222; match to protein family HMM PF02655. | Phosphoribosylaminoimidazolesuccinocarboxamide synthase; Identified by match to protein family HMM PF01259; match to protein family HMM TIGR00081; Belongs to the SAICAR synthetase family. | 0.981 |
