STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Cooccurrence
Coexpression
Experiments
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[Homology]
Score
ilvBAcetolactate synthase, large subunit, biosynthetic type; Identified by similarity to SP:P37251; match to protein family HMM PF00205; match to protein family HMM PF02775; match to protein family HMM PF02776; match to protein family HMM TIGR00118. (572 aa)    
Predicted Functional Partners:
ilvN
Acetolactate synthase, small subunit; Identified by match to protein family HMM PF01842; match to protein family HMM TIGR00119.
 0.999
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
 
 0.955
ilvD
Dihydroxy-acid dehydratase; Identified by similarity to SP:P05791; match to protein family HMM PF00920; match to protein family HMM TIGR00110; Belongs to the IlvD/Edd family.
 
 0.925
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
 0.909
leuA
2-isopropylmalate synthase; Identified by similarity to SP:P09151; match to protein family HMM PF00682; match to protein family HMM PF08502; Belongs to the alpha-IPM synthase/homocitrate synthase family.
 
 
 0.853
nifJ
Pyruvate synthase; Identified by similarity to SP:P52647; match to protein family HMM PF00037; match to protein family HMM PF01558; match to protein family HMM PF01855; match to protein family HMM TIGR02176.
  
 
 0.810
leuD
3-isopropylmalate dehydratase, small subunit; Identified by similarity to SP:P30126; match to protein family HMM PF00694; match to protein family HMM TIGR00171; Belongs to the LeuD family.
 
 
 0.809
maeB
NADP-dependent malic enzyme; Identified by similarity to SP:P76558; match to protein family HMM PF00390; match to protein family HMM PF01515; match to protein family HMM PF03949.
  
 0.772
FSU_1439
Putative phosphoenolpyruvate mutase; Identified by similarity to GB:AAG26465.1; match to protein family HMM PF01467; match to protein family HMM TIGR00125; match to protein family HMM TIGR02320.
  
 
 0.740
leuC
3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 
 
 0.705
Your Current Organism:
Fibrobacter succinogenes
NCBI taxonomy Id: 59374
Other names: F. succinogenes subsp. succinogenes S85, Fibrobacter succinogenes S85, Fibrobacter succinogenes subsp. succinogenes S85
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