STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AGB01098.1Hypothetical protein. (120 aa)    
Predicted Functional Partners:
AGB01099.1
Hypothetical protein; PFAM: Cysteine-rich small domain; Adenosylcobinamide amidohydrolase.
       0.874
queE
Organic radical activating enzyme; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
  
 
 0.865
grpE
Molecular chaperone GrpE (heat shock protein); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. [...]
  
  
 0.676
AGB02231.1
PFAM: ATP cone domain; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase.
  
     0.666
pyrF
Orotidine 5'-phosphate decarboxylase, subfamily 1; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily.
     
 0.658
AGB01096.1
PFAM: Deoxyhypusine synthase; TIGRFAM: deoxyhypusine synthase.
       0.597
AGB03188.1
Hypothetical protein.
  
     0.566
AGB02688.1
CARDB domain-containing protein; PFAM: CARDB.
  
     0.540
AGB01577.1
S-layer domain-containing protein.
  
     0.531
AGB02027.1
FHA domain-containing protein; PFAM: FHA domain.
 
     0.527
Your Current Organism:
Methanoregula formicica
NCBI taxonomy Id: 593750
Other names: M. formicica SMSP, Methanomicrobiales archaeon SMSP, Methanoregula formicica SMSP, Methanoregula formicica str. SMSP, Methanoregula formicica strain SMSP
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.