Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AGB02068.1Membrane protease subunit, stomatin/prohibitin; PFAM: SPFH domain / Band 7 family. (360 aa)    
Predicted Functional Partners:
AGB02069.1
Membrane-bound serine protease (ClpP class); PFAM: NfeD-like.
 
 
 0.984
AGB01540.1
PFAM: GTPase of unknown function.
  
 0.916
valS
valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
  
 
 0.799
AGB02003.1
PFAM: E1-E2 ATPase; Cation transporting ATPase, C-terminus; Cation transporter/ATPase, N-terminus; haloacid dehalogenase-like hydrolase; TIGRFAM: plasma-membrane calcium-translocating P-type ATPase; ATPase, P-type (transporting), HAD superfamily, subfamily IC.
   
 0.712
AGB03276.1
Plasma-membrane calcium-translocating P-type ATPase; PFAM: E1-E2 ATPase; Cation transporting ATPase, C-terminus; Cation transporter/ATPase, N-terminus; haloacid dehalogenase-like hydrolase; TIGRFAM: plasma-membrane calcium-translocating P-type ATPase; ATPase, P-type (transporting), HAD superfamily, subfamily IC.
   
 0.712
nadE-2
NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
 
   
 0.694
dnaK
Chaperone protein DnaK; Acts as a chaperone.
  
 0.694
AGB03550.1
Molecular chaperone; PFAM: MreB/Mbl protein; Belongs to the heat shock protein 70 family.
  
 0.694
AGB02568.1
26S proteasome subunit P45 family; PFAM: ATPase family associated with various cellular activities (AAA); TIGRFAM: 26S proteasome subunit P45 family; Belongs to the AAA ATPase family.
   
 
 0.664
pan
26S proteasome subunit P45 family; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-2 [...]
   
 
 0.664
Your Current Organism:
Methanoregula formicica
NCBI taxonomy Id: 593750
Other names: M. formicica SMSP, Methanomicrobiales archaeon SMSP, Methanoregula formicica SMSP, Methanoregula formicica str. SMSP, Methanoregula formicica strain SMSP
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