Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
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[Homology]
Score
AGB02938.1PFAM: Protein kinase domain. (585 aa)    
Predicted Functional Partners:
AGB01540.1
PFAM: GTPase of unknown function.
   
 0.985
dnaJ
Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]
  
 0.971
dnaK
Chaperone protein DnaK; Acts as a chaperone.
  
 0.967
AGB03550.1
Molecular chaperone; PFAM: MreB/Mbl protein; Belongs to the heat shock protein 70 family.
  
 0.967
AGB01655.1
SET domain-containing protein; PFAM: SET domain.
  
 0.945
AGB03549.1
WD40 repeat-containing protein; PFAM: WD domain, G-beta repeat.
 
 0.942
AGB02355.1
ABC-type multidrug transport system, ATPase and permease component; PFAM: ABC transporter.
   
 0.939
rpoD
DNA-directed RNA polymerase, alpha subunit/40 kD subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
  
 0.938
AGB03426.1
DNA/RNA helicase, superfamily II, SNF2 family; PFAM: Helicase conserved C-terminal domain; SNF2 family N-terminal domain.
  
 0.934
AGB02089.1
PFAM: WD domain, G-beta repeat.
  
 0.925
Your Current Organism:
Methanoregula formicica
NCBI taxonomy Id: 593750
Other names: M. formicica SMSP, Methanomicrobiales archaeon SMSP, Methanoregula formicica SMSP, Methanoregula formicica str. SMSP, Methanoregula formicica strain SMSP
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