STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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[Homology]
Score
AGB03136.1Chemotaxis protein CheC, inhibitor of MCP methylation; PFAM: CheC-like family. (206 aa)    
Predicted Functional Partners:
cheD
Chemotaxis protein; Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis; Belongs to the CheD family.
 
 0.999
AGB02550.1
Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains; PFAM: Response regulator receiver domain.
 
 
 0.983
AGB02553.1
Chemotaxis protein CheC, inhibitor of MCP methylation; PFAM: CheC-like family.
  
  
 
0.903
cheB
Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family.
 
  
 0.896
AGB02552.1
Chemotaxis protein histidine kinase-like protein; PFAM: CheW-like domain; P2 response regulator binding domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Signal transducing histidine kinase, homodimeric domain; Hpt domain.
  
 0.883
AGB02906.1
Chemotaxis protein histidine kinase-like protein; PFAM: CheW-like domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; Hpt domain.
 
  
 0.767
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
   
 
 0.757
AGB02905.1
PFAM: HAMP domain; Cache domain; Methyl-accepting chemotaxis protein (MCP) signaling domain.
 
 
 0.755
AGB02795.1
PFAM: Semialdehyde dehydrogenase, dimerisation domain; Semialdehyde dehydrogenase, NAD binding domain; TIGRFAM: aspartate-semialdehyde dehydrogenase (non-peptidoglycan organisms).
   
   0.747
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
   
   0.747
Your Current Organism:
Methanoregula formicica
NCBI taxonomy Id: 593750
Other names: M. formicica SMSP, Methanomicrobiales archaeon SMSP, Methanoregula formicica SMSP, Methanoregula formicica str. SMSP, Methanoregula formicica strain SMSP
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