G1NTP5_MYOLU protein (Myotis lucifugus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

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Textmining

[Homology]

Score

G1NTP5_MYOLU

Uncharacterized protein. (504 aa)

Predicted Functional Partners:

RABEP2

0.999

RAB21

0.999

RABEP1

0.999

RAB24

0.993

RAB17

0.991

RAB22A

0.989

RAB5C

0.988

RAB5B

0.987

RAB5A

0.987

RAB20

0.987

Your Current Organism:

Myotis lucifugus

NCBI taxonomy Id: 59463
Other names: M. lucifugus, little brown bat

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... functional annotations:

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
G1NTP5_MYOLU	RAB17	ENSMLUP00000000550	ENSMLUP00000000403	Uncharacterized protein.	RAB17, member RAS oncogene family.	0.991
G1NTP5_MYOLU	RAB20	ENSMLUP00000000550	ENSMLUP00000016068	Uncharacterized protein.	RAB20, member RAS oncogene family.	0.987
G1NTP5_MYOLU	RAB21	ENSMLUP00000000550	ENSMLUP00000012046	Uncharacterized protein.	RAB21, member RAS oncogene family.	0.999
G1NTP5_MYOLU	RAB22A	ENSMLUP00000000550	ENSMLUP00000007847	Uncharacterized protein.	RAB22A, member RAS oncogene family.	0.989
G1NTP5_MYOLU	RAB24	ENSMLUP00000000550	ENSMLUP00000019371	Uncharacterized protein.	RAB24, member RAS oncogene family.	0.993
G1NTP5_MYOLU	RAB5A	ENSMLUP00000000550	ENSMLUP00000010664	Uncharacterized protein.	RAB5A, member RAS oncogene family.	0.987
G1NTP5_MYOLU	RAB5B	ENSMLUP00000000550	ENSMLUP00000003281	Uncharacterized protein.	RAB5B, member RAS oncogene family.	0.987
G1NTP5_MYOLU	RAB5C	ENSMLUP00000000550	ENSMLUP00000010956	Uncharacterized protein.	Uncharacterized protein.	0.988
G1NTP5_MYOLU	RABEP1	ENSMLUP00000000550	ENSMLUP00000013108	Uncharacterized protein.	Rabaptin, RAB GTPase binding effector protein 1.	0.999
G1NTP5_MYOLU	RABEP2	ENSMLUP00000000550	ENSMLUP00000009112	Uncharacterized protein.	Rabaptin, RAB GTPase binding effector protein 2.	0.999
RAB17	G1NTP5_MYOLU	ENSMLUP00000000403	ENSMLUP00000000550	RAB17, member RAS oncogene family.	Uncharacterized protein.	0.991
RAB17	RAB21	ENSMLUP00000000403	ENSMLUP00000012046	RAB17, member RAS oncogene family.	RAB21, member RAS oncogene family.	0.515
RAB17	RABEP1	ENSMLUP00000000403	ENSMLUP00000013108	RAB17, member RAS oncogene family.	Rabaptin, RAB GTPase binding effector protein 1.	0.924
RAB17	RABEP2	ENSMLUP00000000403	ENSMLUP00000009112	RAB17, member RAS oncogene family.	Rabaptin, RAB GTPase binding effector protein 2.	0.745
RAB20	G1NTP5_MYOLU	ENSMLUP00000016068	ENSMLUP00000000550	RAB20, member RAS oncogene family.	Uncharacterized protein.	0.987
RAB20	RAB21	ENSMLUP00000016068	ENSMLUP00000012046	RAB20, member RAS oncogene family.	RAB21, member RAS oncogene family.	0.450
RAB20	RABEP1	ENSMLUP00000016068	ENSMLUP00000013108	RAB20, member RAS oncogene family.	Rabaptin, RAB GTPase binding effector protein 1.	0.745
RAB20	RABEP2	ENSMLUP00000016068	ENSMLUP00000009112	RAB20, member RAS oncogene family.	Rabaptin, RAB GTPase binding effector protein 2.	0.745
RAB21	G1NTP5_MYOLU	ENSMLUP00000012046	ENSMLUP00000000550	RAB21, member RAS oncogene family.	Uncharacterized protein.	0.999
RAB21	RAB17	ENSMLUP00000012046	ENSMLUP00000000403	RAB21, member RAS oncogene family.	RAB17, member RAS oncogene family.	0.515

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

21

average node degree:

3.82

avg. local clustering coefficient:

0.904

expected number of edges:

11

PPI enrichment p-value:

0.00438

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0018106

Peptidyl-histidine phosphorylation

8 of 69

1.57

2.69

4.64e-09

GO:0000160

Phosphorelay signal transduction system

9 of 120

1.39

2.19

4.64e-09

GO:0050896

Response to stimulus

11 of 336

1.03

1.3

4.64e-09

GO:0050794

Regulation of cellular process

11 of 352

1.01

1.26

4.64e-09

GO:0006355

Regulation of transcription, DNA-templated

8 of 222

1.07

1.22

2.30e-06

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043565

Sequence-specific DNA binding

7 of 50

1.66

2.88

5.80e-09

GO:0000155

Phosphorelay sensor kinase activity

8 of 73

1.55

2.63

4.72e-09

GO:0003700

DNA-binding transcription factor activity

7 of 93

1.39

1.96

2.24e-07

GO:0003677

DNA binding

8 of 281

0.96

1.0

1.05e-05

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009986

Cell surface

7 of 32

1.85

3.66

3.79e-10

GO:0016021

Integral component of membrane

10 of 699

0.67

0.59

4.59e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3690

His Kinase A (phosphoacceptor) domain, and cheY-homologous receiver domain

10 of 46

1.85

4.83

3.36e-15

CL:3697

PAS domain, and cheY-homologous receiver domain

8 of 28

1.97

4.77

5.44e-13

CL:3691

PAS domain, and cheY-homologous receiver domain

9 of 41

1.85

4.58

5.96e-14

CL:3699

PAS domain, and cheY-homologous receiver domain

6 of 21

1.97

3.74

1.61e-09

CL:3702

PAS domain, and cheY-homologous receiver domain

5 of 16

2.01

3.26

6.33e-08

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02020

Two-component system

11 of 403

0.95

1.13

5.70e-09

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0418

Kinase

9 of 127

1.36

2.18

1.35e-09

KW-0597

Phosphoprotein

6 of 74

1.42

1.79

4.45e-06

KW-0067

ATP-binding

7 of 215

1.02

1.03

4.39e-05

KW-0902

Two-component regulatory system

2 of 12

1.73

0.84

0.0222

KW-0175

Coiled coil

6 of 248

0.89

0.73

0.0014

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR004358

Signal transduction histidine kinase-related protein, C-terminal

9 of 44

1.82

4.18

1.25e-12

IPR003661

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain

9 of 51

1.76

3.9

2.08e-12

IPR005467

Histidine kinase domain

9 of 52

1.75

3.87

2.08e-12

IPR036097

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily

9 of 54

1.73

3.81

2.08e-12

IPR003594

Histidine kinase/HSP90-like ATPase

9 of 60

1.69

3.61

3.17e-12

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00388

His Kinase A (phosphoacceptor) domain

10 of 60

1.73

4.27

4.94e-15

SM00387

Histidine kinase-like ATPases

9 of 63

1.67

3.62

9.28e-13

SM00091

PAS domain

6 of 26

1.87

3.4

4.98e-09

SM00086

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)

5 of 24

1.83

2.77

2.90e-07

SM00448

cheY-homologous receiver domain

6 of 68

1.46

2.03

5.81e-07

(more ...)

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