MIER3 protein (Myotis lucifugus) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

MIER3

Uncharacterized protein. (546 aa)

Predicted Functional Partners:

CDYL

0.697

CDYL2

0.697

G1Q0R8_MYOLU

0.619

DNTTIP1

0.619

C16orf87

0.616

BAHD1

0.606

CTBS

0.570

CYBRD1

0.495

SLC9A9

0.489

TCERG1

0.489

Your Current Organism:

Myotis lucifugus

NCBI taxonomy Id: 59463
Other names: M. lucifugus, little brown bat

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structured XML interaction data, according to the 'PSI-MI' data standard

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... protein annotations:

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... functional annotations:

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BAHD1	MIER3	ENSMLUP00000016027	ENSMLUP00000000595	Bromo adjacent homology domain containing 1.	Uncharacterized protein.	0.606
C16orf87	MIER3	ENSMLUP00000003660	ENSMLUP00000000595	Chromosome 16 open reading frame 87.	Uncharacterized protein.	0.616
CDYL	CDYL2	ENSMLUP00000000450	ENSMLUP00000001290	Chromodomain Y like.	Chromodomain Y like 2.	0.787
CDYL	CYBRD1	ENSMLUP00000000450	ENSMLUP00000012466	Chromodomain Y like.	Cytochrome b reductase 1.	0.699
CDYL	MIER3	ENSMLUP00000000450	ENSMLUP00000000595	Chromodomain Y like.	Uncharacterized protein.	0.697
CDYL2	CDYL	ENSMLUP00000001290	ENSMLUP00000000450	Chromodomain Y like 2.	Chromodomain Y like.	0.787
CDYL2	CYBRD1	ENSMLUP00000001290	ENSMLUP00000012466	Chromodomain Y like 2.	Cytochrome b reductase 1.	0.597
CDYL2	MIER3	ENSMLUP00000001290	ENSMLUP00000000595	Chromodomain Y like 2.	Uncharacterized protein.	0.697
CTBS	MIER3	ENSMLUP00000014612	ENSMLUP00000000595	Chitobiase; Belongs to the glycosyl hydrolase 18 family.	Uncharacterized protein.	0.570
CYBRD1	CDYL	ENSMLUP00000012466	ENSMLUP00000000450	Cytochrome b reductase 1.	Chromodomain Y like.	0.699
CYBRD1	CDYL2	ENSMLUP00000012466	ENSMLUP00000001290	Cytochrome b reductase 1.	Chromodomain Y like 2.	0.597
CYBRD1	MIER3	ENSMLUP00000012466	ENSMLUP00000000595	Cytochrome b reductase 1.	Uncharacterized protein.	0.495
DNTTIP1	MIER3	ENSMLUP00000019815	ENSMLUP00000000595	DNTTIP1_dimer domain-containing protein.	Uncharacterized protein.	0.619
G1Q0R8_MYOLU	MIER3	ENSMLUP00000017300	ENSMLUP00000000595	DNTTIP1_dimer domain-containing protein.	Uncharacterized protein.	0.619
MIER3	BAHD1	ENSMLUP00000000595	ENSMLUP00000016027	Uncharacterized protein.	Bromo adjacent homology domain containing 1.	0.606
MIER3	C16orf87	ENSMLUP00000000595	ENSMLUP00000003660	Uncharacterized protein.	Chromosome 16 open reading frame 87.	0.616
MIER3	CDYL	ENSMLUP00000000595	ENSMLUP00000000450	Uncharacterized protein.	Chromodomain Y like.	0.697
MIER3	CDYL2	ENSMLUP00000000595	ENSMLUP00000001290	Uncharacterized protein.	Chromodomain Y like 2.	0.697
MIER3	CTBS	ENSMLUP00000000595	ENSMLUP00000014612	Uncharacterized protein.	Chitobiase; Belongs to the glycosyl hydrolase 18 family.	0.570
MIER3	CYBRD1	ENSMLUP00000000595	ENSMLUP00000012466	Uncharacterized protein.	Cytochrome b reductase 1.	0.495

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

43

average node degree:

7.82

avg. local clustering coefficient:

0.868

expected number of edges:

24

PPI enrichment p-value:

0.000262

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:200

Carbon metabolism, and Valine, leucine and isoleucine degradation

11 of 101

1.61

3.76

2.87e-15

CL:252

Mixed, incl. Biotin-lipoyl like, and Geraniol degradation

4 of 5

2.48

3.33

4.18e-07

CL:302

Citrate cycle (TCA cycle), and Glyoxylate and dicarboxylate metabolism

7 of 50

1.72

3.12

2.88e-09

CL:306

Citrate cycle (TCA cycle), and Aminotransferase, class I/classII

4 of 22

1.84

2.02

4.24e-05

CL:386

Methylmalonyl-CoA mutase

2 of 5

2.18

1.11

0.0084

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00280

Valine, leucine and isoleucine degradation

5 of 28

1.83

2.56

1.22e-06

map00650

Butanoate metabolism

4 of 32

1.67

1.82

5.94e-05

map00020

Citrate cycle (TCA cycle)

3 of 25

1.66

1.38

0.0010

map01200

Carbon metabolism

5 of 115

1.22

1.18

0.00022

map01120

Microbial metabolism in diverse environments

7 of 236

1.05

1.08

3.42e-05

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009317

acetyl-CoA carboxylase complex

3 of 6

2.28

1.88

0.00026

GOCC:0032991

Protein-containing complex

6 of 390

0.76

0.47

0.0252

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF17147

Pyruvate:ferredoxin oxidoreductase core domain II

2 of 2

2.58

0.93

0.0204

PF01855

Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg

2 of 2

2.58

0.93

0.0204

PF01558

Pyruvate ferredoxin/flavodoxin oxidoreductase

2 of 2

2.58

0.93

0.0204

PF01642

Methylmalonyl-CoA mutase

2 of 4

2.28

0.92

0.0204

PF01039

Carboxyl transferase domain

2 of 3

2.4

0.92

0.0204

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR033412

Pyruvate:ferredoxin oxidoreductase, core domain II

2 of 2

2.58

0.8

0.0356

IPR019752

Pyruvate/ketoisovalerate oxidoreductase, catalytic domain

2 of 2

2.58

0.8

0.0356

IPR011762

Acetyl-coenzyme A carboxyltransferase, N-terminal

2 of 2

2.58

0.8

0.0356

IPR002880

Pyruvate flavodoxin/ferredoxin oxidoreductase, pyrimidine binding domain

2 of 2

2.58

0.8

0.0356

IPR002869

Pyruvate-flavodoxin oxidoreductase, central domain

2 of 2

2.58

0.8

0.0356

(more ...)

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